Evidence map›Paper›PMID 35071044›Full record

ArticleFrontiers in cellular and infection microbiology2021

Vaccine Protection of Mice With Primary Immunodeficiencies Against Disseminated Coccidioidomycosis.

Daniel A Powell, Amy P Hsu, Christine D Butkiewicz, Hien T Trinh, Jeffrey A Frelinger, Steven M Holland, John N Galgiani, Lisa F Shubitz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. From soil to clinic: current advances in understandingMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  4. Article
  5. The Host Response to Coccidioidomycosis.Journal of fungi (Basel, Switzerland) · 2024
    Review
  6. Review
  7. Review
  8. Current Landscape of Coccidioidomycosis.Journal of fungi (Basel, Switzerland) · 2022
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniel A PowellValley Fever Center for Excellence, University of Arizona, Tucson, AZ, United States.
Amy P HsuLaboratory of Clinical and Infectious Diseases, National Institutes of Allergy and Infectious Disease, Bethesda, MD, United States.
Christine D ButkiewiczValley Fever Center for Excellence, University of Arizona, Tucson, AZ, United States.
Hien T TrinhValley Fever Center for Excellence, University of Arizona, Tucson, AZ, United States.
Jeffrey A FrelingerValley Fever Center for Excellence, University of Arizona, Tucson, AZ, United States.
Steven M HollandLaboratory of Clinical and Infectious Diseases, National Institutes of Allergy and Infectious Disease, Bethesda, MD, United States.
John N GalgianiValley Fever Center for Excellence, University of Arizona, Tucson, AZ, United States.
Lisa F ShubitzValley Fever Center for Excellence, University of Arizona, Tucson, AZ, United States.
University of Arizona · USNational Institute of Allergy and Infectious Diseases · US

Funding

An Avirulent Arthroconidial Vaccine Candidate to Prevent Human CoccidioidomycosisR01AI132140 · NIAID · UNIVERSITY OF ARIZONA · PI GALGIANI, JOHN N · 2017 to 2020
$4.8M
Immuno-Genetic Basis for Human Disseminated CoccidioidomycosisU01AI122275 · NIAID · UNIVERSITY OF ARIZONA · PI GALGIANI, JOHN N, HOLLAND, STEVEN M · 2017 to 2020
$2.3M
NIAID NIH HHS R01 AI132140NIAID NIH HHS U01 AI122275
6 · The paper itself

Abstract

Disseminated coccidioidomycosis (DCM), often a severe and refractory disease leading to poor outcomes, is a risk for people with certain primary immunodeficiencies (PID). Several DCM-associated PID (STAT4, STAT3, IFNγ, and Dectin-1) are modeled in mice. To determine if vaccination could provide these mice protection, mice with mutations in

Indexed as

CoccidioidomycosisFungal VaccinesAnimalsLungMiceMice, Inbred C57BLVaccines, AttenuatedFungal VaccinesVaccines, Attenuatedcoccidioidomycosisdisseminatedimmunodeficiencymicevaccine

Identifiers

PMID35071044
PMCPMC8777018
OpenAlexW4205456491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.