ArticleGland surgery2021
Systematic review and meta-analysis of the diagnostic value of radionuclide imaging for thyroid nodules.
Article in Gland surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Doppler-Scintigraphy Combination with Thyroxine Profiling Enhances Diagnostic Accuracy of Thyroid Lesions: A 144-Patient Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Application of thyroglobulin and anti-thyroglobulin antibody combined with emission computed tomography in the adjuvant diagnosis of differentiated thyroid carcinoma.Annals of medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are many studies on diagnostic imaging of thyroid nodules, among which radionuclide scanning imaging has been proven to be very effective in identifying malignant lesions of thyroid nodules and is now widely used in the clinical detection of thyroid nodules.
methodsStudies on radionuclide imaging in the diagnosis of thyroid nodules were searched in multiple Chinese and English databases, including PubMed, Web of Science, Embase, and The Cochrane Library as of July 1, 2021. The search terms included "clinical experiment", "thyroid nodule", "radionuclide imaging", "thyroid mass", "thyroid masses", "postoperative pathology", and "histopathology". The basic information and evaluation indicators in the literature were screened and extracted. Subsequently, meta-analysis was performed using RevMan 5.3 and Stata 13 software provided by the Cochrane system. In addition, forest plots and summary receiver operating characteristic (SROC) curves were drawn.
resultsSeven randomized controlled trails (RCTs) were included in this study. The radionuclide imaging of thyroid nodule showed the area under SROC curve of 0.38. The combined diagnostic sensitivity and specificity were 0.66 [95% confidence interval (CI): 0.46, 0.89] and 0.36 (95% CI: 0.21, 0.59), respectively. The combined positive likelihood ratio (LR) and negative LR were 0.66 (95% CI: 0.53, 0.87) and 0.67 (95% CI: 0.43, 0.95), respectively. In addition, the combined diagnostic odds ratio (OR) was 4.45 (95% CI: 0.25, 10.57). DISCUSSION: In this study, meta-analysis was used to confirm the application value of radionuclide imaging in the diagnosis of thyroid nodules. In the future, the value of radionuclide imaging in the diagnosis of thyroid nodules should be compared with other imaging detection methods.
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