Evidence map›Paper›PMID 35070845›Full record

ArticleTranslational pediatrics2021

Antley-Bixler syndrome arising from compound heterozygotes in the P450 oxidoreductase gene: a case report.

Haibo Li, Aman Zhao, Min Xie, Linqi Chen, Haiying Wu, Yiping Shen, Hongying Wang

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Novel compound heterozygousFrontiers in endocrinology · 2026
    Review
  4. The Central Role of Cytochrome P450 Reductase (CPR) in Hyperoxic Lung Injury.Expert opinion on drug metabolism & toxicology · 2025
    Review
  5. [Audiological phenotypes of Antlet-Bixler syndrome: a case report and literatures review].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Haibo LiThe Central Laboratory of Birth Defects Prevention and Control, Ningbo Women and Children's Hospital, Ningbo, China.
Aman ZhaoDepartment of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Min XieThe Central Laboratory of Birth Defects Prevention and Control, Ningbo Women and Children's Hospital, Ningbo, China.
Linqi ChenDepartment of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Haiying WuDepartment of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Yiping ShenDivision of Genetics and Genomics, Department of Medicine, Boston Children's Hospital, Boston, MA, USA.
Hongying WangDepartment of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Soochow University · CNHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antley-Bixler syndrome (ABS) arising from P450 oxidoreductase deficiency (PORD) is a rare, distinct craniosynostosis syndrome, accompanied by ambiguous genitalia and impaired steroidogenesis. It is reported that this disorder is caused by mutations in the P450 oxidoreductase (

Indexed as

ambiguous genitaliaAntley-Bixler syndrome (ABS)Case reportexome sequencingP450 oxidoreductase (POR)

Identifiers

PMID35070845
PMCPMC8753478
OpenAlexW4206238398

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.