ArticleTranslational pediatrics2021
Comparison between dexmedetomidine and esketamine in pediatric dentistry surgery.
Article in Translational pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Intranasal dexmedetomidine versus midazolam for pediatric dental sedation: a pooled analysis of clinical trials.Frontiers in medicine · 2026Pooled it
- Optimal doses of intranasal esketamine plus dexmedetomidine for sedating toddlers during transthoracic echocardiography: a prospective, double-blind, randomized trial.Annals of medicine · 2025Trial
- Effect of intravenous different drugs on the prevention of restlessness during recovery period of pediatric laparoscopic surgery: a randomized control trial.Journal of anesthesia · 2025Trial
- Review
- Comparative evaluation of the effectiveness and acceptance of intranasal dexmedetomidine and intranasal midazolam for sedation in children aged 5-8 years using a mucosal atomizer device: a randomized controlled clinical study.Journal of dental anesthesia and pain medicine · 2025Article
- Esketamine combined with ultrasound-guided superficial cervical plexus block to complete pediatric subglottic stenosis tracheotomy-a case report and literature review.BMC anesthesiology · 2025Review
- Anesthesia management in a pediatric patient with complicatedly difficult airway: A case report.World journal of clinical cases · 2023Article
- The use of Esketamine in CT-guided percutaneous liver tumor ablation reduces the consumption of remifentanil: a randomized, controlled, double-blind trial.Annals of translational medicine · 2022Article
- The safety and efficacy of esketamine in comparison to dexmedetomidine during drug-induced sleep endoscopy in children with obstructive sleep apnea hypopnea syndrome: A randomized, controlled and prospective clinical trial.Frontiers in pharmacology · 2022Article
- Comment on "Dexmedetomidine sedation for a dental extraction in a patient with known difficult airway".Anaesthesia reportsArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDexmedetomidine (D) and esketamine (K) are used for the sedation of pediatric dental surgery. This study was designed to compare the effect of intranasal D and K in producing moderate sedation for uncooperative pediatric dental patients.
methodsThis prospective single-center cohort study was conducted at the Maternal and Child Health Hospital of Hubei Province after approval of the Medical Ethics Committee. One hundred and fifty American Society of Anesthesiologists (ASA) grade I and II patients aged 3-10 years who were uncooperative and could not be managed by conventional behavior management techniques were included in this study. Patients were classified into four groups. Group K was administered with esketamine (0.5 mg/kg), and group D was given D1 (1 µg/kg), D2 (1.5 µg/kg), or D3 (2.0 µg/kg) intranasally. The outcome measurements included the sedation level, changes in vital signs, sedation onset and recovery times, analgesia, behavior, and overall success.
resultsThe sedation onset time was significantly shorter for K and D3 compared with D1 and D2. The recovery time was fastest in group D1. The overall success rate was highest in group D3, followed by the D2, D1, and K groups; however, the difference between them was not significant. The intra-and postoperative pain scores in the D3 and K groups were significantly lower than those in the D1 group.
conclusionsIntranasal D and K are effective in producing moderate sedation for uncooperative pediatric dental patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.