ArticleTranslational andrology and urology2021
Kidney stone disease and cardiovascular events: a study on bidirectional causality based on mendelian randomization.
Article in Translational andrology and urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Pooled it
- Causal effects of modifiable risk factors on kidney stones: a bidirectional mendelian randomization study.BMC medical genomics · 2023Pooled it
- Combined occurrence of cardiovascular and bone events in individuals with kidney stone disease.Clinical kidney journal · 2026Article
- Identification of cardiovascular disease in patients with kidney stone disease using explainable machine learning.Frontiers in cardiovascular medicine · 2026Article
- Genitourinary system related tumors and coronary atherosclerosis risk: Evidence from a Mendelian randomization study on multi-cohorts.Translational oncology · 2025Article
- Analysis of risk factors for kidney stones in patients with hyperuricemia: a cross-sectional study based on NHANES.Translational andrology and urology · 2025Article
- Kidney stone and risk of cardiovascular diseases: a cross-sectional study in the southeast of Iran.BMC nephrology · 2025Article
- Article
- Research trends and frontiers on risk factors of urinary stones: a bibliometric analysis from 2010 to 2023.Renal failure · 2024Article
- Global Trends in Kidney Stone Awareness: A Time Series Analysis from 2004-2023.Clinics and practice · 2024Article
- Porous Se@SiOTranslational andrology and urology · 2024Article
- Article
- Article
- Sex disparities and the risk of urolithiasis: a large cross-sectional study.Annals of medicine · 2022Article
- Genetically supported causality between benign prostate hyperplasia and urinary bladder neoplasms: A mendelian randomization study.Frontiers in genetics · 2022Article
- Association between body fat distribution and kidney stones: Evidence from a US population.Frontiers in endocrinology · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKidney stone disease (KSD) has been reported to be associated with several cardiovascular diseases. However, the causality between the conditions remains unknown. In the study, we performed a study on bidirectional causality by two-sample Mendelian randomization (MR) to investigate the causality between KSD and cardiovascular diseases including coronary atherosclerosis, hypertension, and cardiomyopathy.
methodsIn the recent study, we performed a bidirectional two-sample MR study using available genome-wide association summary data from the online database MRBASE. We identified genetic variants associated with KSD in one European population from UK Biobank (version 2, n=462,933). Two phenotypes of samples were chosen from the population to define our genetic instrumental variables: (I) samples with the phenotype of kidney stone/ureter stone/bladder stone (ukb-b-8297), and (II) samples with the phenotype of kidney stone surgery/lithotripsy (ukb-b-13537). For cardiovascular diseases, we picked up another independent European population from FinnGen Biobank (n=93,421). We selected the exposure and outcome SNPs and then performed the two-sample MR using R package.
resultsAfter bidirectional causality by two-sample MR, we verified that genetic predisposition to KSD could increase the risk of coronary atherosclerosis (OR: 4.45×1037; SE=±7.80×10
conclusionsWe confirmed KSD may trigger causal pathological processes including coronary atherosclerosis and cardiomyopathy. Furthermore, hypertension may causally affect KSD.
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