ArticleTranslational andrology and urology2021
E3 ubiquitin ligase ASB17 is required for spermiation in mice.
Article in Translational andrology and urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 17 citations in OpenAlex.
- TRIM15 Mediates ubiquitination of Paxillin to facilitate the progression of ovarian cancer.Cancer cell international · 2026Article
- ASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Potential Role of Deubiquitinating Enzymes (DUBs) in Male Fertility.Biomolecules · 2026Review
- WSB1 is dispensable for mouse spermatogenesis and male fertility.American journal of translational research · 2026Article
- High-resolution optical genome mapping unveils gene disruptions in a reciprocal chromosomal translocation and severe male infertility: a case report.Journal of assisted reproduction and genetics · 2025Article
- ASB1 engages with ELOB to facilitate SQOR ubiquitination and HRedox biology · 2025Article
- DCUN1D2 is insignificant for spermatogenesis and male fertility in mice.American journal of translational research · 2025Article
- Article
- Testis-enrichedAmerican journal of translational research · 2025Article
- Testis-enrichedAmerican journal of translational research · 2025Article
- Article
- Transcriptomic Characterization of Male Formosan Pangolin (Animals : an open access journal from MDPI · 2024Article
- E3 ligase FBXO22 is not significant for spermatogenesis and male fertility in mice.American journal of translational research · 2024Article
- Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway.Cell death & disease · 2023Article
- Article
- Identification of proline-rich protein 11 as a major regulator in mouse spermatogonia maintenance via an increase in BMI1 protein stability.Molecular biology reports · 2022Article
- Application of CRISPR/Cas Technology in Spermatogenesis Research and Male Infertility Treatment.Genes · 2022Review
- Testis-enrichedAmerican journal of translational research · 2022Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA major goal of spermiation is to degrade the apical ectoplasmic specialization (ES) junction between Sertoli cells and elongating spermatids in preparation for the eventual disengagement of spermatids into the lumen. E3 ubiquitin ligases mediate the process of ubiquitination and the subsequent proteasomal degradation, but their specific role during spermiation remains largely unexplored.
methodsAnkyrin repeat and SOCS box protein 17 (
resultsWe report that ASB17, an E3 ligase, is required for the completion of spermiation and that mice lacking
conclusionsIn summary, our study describes a role for ASB17 in the regulation of cell-cell junctions between germ cells and somatic cells in the testis. These findings establish a novel mechanism for the regulatory role of E3 ligases during spermatogenesis.
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