ArticleJournal of microscopy and ultrastructure
Modulation of Telocytes in Women with Preeclampsia: A Prospective Comparative Study.
Article in Journal of microscopy and ultrastructure. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- mRNA Expression to Assess Hypoxia and Angiogenesis in Decidual Tissue of Term Fetuses With a Congenital Heart Disease.Prenatal diagnosis · 2025Article
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Telocytes in the Female Reproductive System: Up-to-Date Knowledge, Challenges and Possible Clinical Applications.Life (Basel, Switzerland) · 2022Review
- Telocyte-Derived Exosomes Provide an Important Source of Wnts That Inhibits Fibrosis and Supports Regeneration and Repair of Endometrium.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTelocytes (TCs) are networking cells with enigmatic functions. Placenta is a noninnervated organ with the TCs could have function of signal transmission to placental myofibroblasts, being likely a regulator for maternal blood flow. Preeclampsia (PE) is a disease complicating the second half of pregnancy associated with hypoxia probably due to failure of vascular remodeling of spiral arteries resulting in poor placental perfusion. We hypothesized that disturbance in the morphology of TCs may have a role in the pathogenesis of PE. MATERIALS AND
methodsWomen with normal or physiological pregnancy (Group I; 15 women) and with PE (Group II; 15 women) participated in this study. Specimens were obtained from the central cotyledons and the superficial myometrium beneath the implantation sites processed for light microscopy and stained with Hematoxylin and Eosin, toluidine blue, masson trichrome, and CD117.
resultsThe villi of group II has thick-walled blood vessels with increased peri-villous fibrinoid deposition, reduced areas of vasculosyncytial membrane and apparent increase in connective tissue density. Morphometric study and statistical analysis revealed a significant increase in the mean number of syncytial knots and significant decrease in placental (villous and decidual) and myometrial TCs and extravillous trophoblasts (EVTs) beneath the placental implantation site in Group II (
conclusionsPE is associated with significantly low number of placental TCs interestingly with low number of EVTs. Further studies are needed to support our findings.
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Registered trials
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