Evidence map›Paper›PMID 35070435›Full record

ArticleJournal of gastrointestinal oncology2021

Hepatoid esophagogastric adenocarcinoma and tumoral heterogeneity: a case report.

Tiago Biachi de Castria, Laura Tang, Marcello Moro Queiroz, Beatriz Mendes Awni, Viktoriya Paroder, Ali Shamseddine, Giovanni Mendonca Bariani, Deborah Mukherji, Charbel F Matar, Gustavo Dos Santos Fernandes and 6 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Journal of gastrointestinal oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Tiago Biachi de CastriaCentro de Oncologia, Hospital Sírio-Libanês, São Paulo, SP, Brasil.
Laura TangMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Marcello Moro QueirozCentro de Oncologia, Hospital Sírio-Libanês, São Paulo, SP, Brasil.
Beatriz Mendes AwniCentro de Oncologia, Hospital Sírio-Libanês, São Paulo, SP, Brasil.
Viktoriya ParoderMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Ali ShamseddineAmerican University of Beirut, Beirut, Lebanon.
Giovanni Mendonca BarianiCentro de Oncologia, Hospital Sírio-Libanês, São Paulo, SP, Brasil.
Deborah MukherjiAmerican University of Beirut, Beirut, Lebanon.
Charbel F MatarAmerican University of Beirut, Beirut, Lebanon.
Gustavo Dos Santos FernandesCentro de Oncologia, Hospital Sírio-Libanês, São Paulo, SP, Brasil.
Ashwaq El-OlayanNational Guard Hospital, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.
Fouad SabatinNational Guard Hospital, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.
Rawad Elias
Ranju Gupta
Yelena Y JanjigianMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Ghassan K Abou-AlfaMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Hospital Sírio-Libanês · BRAmerican University of Beirut · LBCornell University · USKing Abdulaziz Medical City · SAMemorial Sloan Kettering Cancer Center · USHartford Hospital · USLehigh Valley Hospital-Pocono · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Hepatoid adenocarcinoma of the stomach is an uncommon subtype of gastric cancer remarkably similar to hepatocellular carcinoma in histopathological analysis. It is also commonly associated with high serum alfa-fetoprotein and a poorer prognosis, despite the emergence of new therapeutic options. In recent years, next generation sequencing (NGS) technology has made it possible to identify and describe the genes and molecular alterations common to gastric cancer thereby contributing to the advancement of targeted therapies. A 62-year-old patient, with no prior risk factor for hepatocellular carcinoma (HCC), presented to the emergency room with dysphagia for solids, abdominal pain and weight loss of about 3 kilograms over 3 months. Histopathological analysis presented with disparities regarding HER2 and programmed death-ligand 1 (PD-L1) status in the primary and metastatic sites. We describe a case of a

Indexed as

Case reportesophagogastric junctionhepatoid adenocarcinomaheterogeneityhuman epidermal growth factor receptor 2 (HER2)

Identifiers

PMID35070435
PMCPMC8748022
OpenAlexW4206010843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.