ArticleAnnals of medicine and surgery (2012)2022
Relationship of serum copper and HLADR4 tissue typing to disease activity and severity in patients with rheumatoid arthritis: A cross sectional study.
Article in Annals of medicine and surgery (2012), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Research Progress of Cuproptosis in Orthopaedics: Opportunities and Challenges.Journal of cellular and molecular medicine · 2026Review
- Nonlinear Relationship of Leukocyte-to-Albumin Ratio with Disease Activity in Rheumatoid Arthritis.Journal of inflammation research · 2026Article
- A retrospective cohort study in China: association betweenFrontiers in medicine · 2026Article
- The Daily Intake Levels of Copper, Selenium, and Zinc Are Associated with Osteoarthritis but Not with Rheumatoid Arthritis in a Cross-sectional Study.Biological trace element research · 2023Article
- Carnosine, Zinc and Copper: A Menage a Trois in Bone and Cartilage Protection.International journal of molecular sciences · 2023Review
- Integrated metabolomics and network analysis reveal changes in lipid metabolisms of tripterygium glycosides tablets in rats with collagen-induced arthritis.Computational and structural biotechnology journal · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundRheumatoid arthritis is a chronic disabling disease associated with high burden on individuals and national health system. Early detection of rheumatoid arthritis is helpful in management and preventing further complications.
objectiveTo assess the relationship between each of serum copper and human leukocyte antigen (HLA)-DR tissue typing with the activity and severity of rheumatoid arthritis.
methodsThis study was an observational prospective cross sectional study implemented in the Rzgary general teaching hospital in Erbil governorate-Iraq from November 1, 2019, to October 31, 2020. Study sample included fifty rheumatoid arthritis patients. The diagnosis of rheumatoid arthritis was done according to 2010-American College of Rheumatology-European League against Rheumatism criteria. The serum copper and HLA-DR4 typing were assessed in regard to activity and severity of rheumatoid arthritis patients.
resultsThis study found that high serum copper level was directly related to both active and severe rheumatoid arthritis disease (p < 0.001). Additionally, this study revealed that positive HLADR4 typing was related to severe rheumatoid arthritis disease (p < 0.001). This study revealed no significant relationship between rheumatoid arthritis activity and severity with HLADR4 subtypes.
conclusionsThe serum copper level and HLA-DR typing of patients with rheumatoid arthritis may be useful in prediction of rheumatoid arthritis disease activity and severity.
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