Evidence map›Paper›PMID 35070170›Full record

ArticleComputational and structural biotechnology journal2022

Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant

Mei-Ling Han, Sue C Nang, Yu-Wei Lin, Yan Zhu, Heidi H Yu, Hasini Wickremasinghe, Christopher K Barlow, Darren J Creek, Simon Crawford, Gauri Rao and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Frontiers in cellular and infection microbiology · 2025
    Article
  6. Phage-antibiotic combinations againstFrontiers in microbiology · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. New Bacteriophages Members of thePHAGE (New Rochelle, N.Y.) · 2023
    Article
  13. Article
  14. Chemical-Biology and Metabolomics Studies in Phage-Host Interactions.Advances in experimental medicine and biology · 2023
    Article
  15. Article
  16. Examining the effects ofFrontiers in genetics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

Mei-Ling HanBiomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Sue C NangBiomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Yu-Wei LinBiomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Yan ZhuBiomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Heidi H YuBiomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Hasini WickremasingheBiomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Christopher K BarlowDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.
Darren J CreekMonash Proteomics and Metabolomics Facility, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
Simon CrawfordRamaciotti Centre for Cryo Electron Microscopy, Monash University, Australia.
Gauri RaoDivision of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
Chongshan DaiDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, No.2 Yuanmingyuan West Road, Beijing 100193, China.
Jeremy J BarrSchool of Biological Sciences, Monash University, 25 Rainforest Walk, Clayton, Victoria 3800, Australia.
Kim ChanAdvanced Drug Delivery Group, School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
Robert Turner SchooleyDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Tony VelkovDepartment of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
Jian LiBiomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
Australian Regenerative Medicine Institute · AUMonash University · AUChina Agricultural University · CNThe University of Melbourne · AUThe University of Sydney · AUUniversity of California San Diego · USUniversity of North Carolina at Chapel Hill · US

Funding

Towards the Translation of Synergistic Phage-Polymyxin Combination Therapy against Pandrug-resistant Klebsiella pneumoniae: A Systems ApproachR21AI156766 · NIAID · MONASH UNIVERSITY · PI LI, JIAN · 2021 to 2022
$348k
NIAID NIH HHS R21 AI156766
6 · The paper itself

Abstract

Resistance to the last-line polymyxins is emerging in multidrug-resistant

Indexed as

BacteriophageCentral carbon metabolismKlebsiella pneumoniaeMetabolomePolymyxin resistance

Identifiers

PMID35070170
PMCPMC8760530
OpenAlexW4206827352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.