Evidence map›Paper›PMID 35070169›Full record

ArticleComputational and structural biotechnology journal2022

Addressing the clinical unmet needs in primary Sjögren's Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts.

Vasileios C Pezoulas, Andreas Goules, Fanis Kalatzis, Luke Chatzis, Konstantina D Kourou, Aliki Venetsanopoulou, Themis P Exarchos, Saviana Gandolfo, Konstantinos Votis, Evi Zampeli and 34 more

Open access · goldAbstract read
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In one paragraph

Article in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 11 countries.

Vasileios C PezoulasUnit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
Andreas GoulesDept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece.
Fanis KalatzisUnit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
Luke ChatzisDept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece.
Konstantina D KourouUnit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
Aliki VenetsanopoulouDept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece.
Themis P ExarchosUnit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
Saviana GandolfoClinic of Rheumatology, Dept. of Medical and Biological Sciences, Udine University, Udine, Italy.
Konstantinos VotisCentre for Research and Technology Hellas, Thermi, Thessaloniki, Greece.
Evi ZampeliInstitute for Systemic Autoimmune and Neurological Diseases, Athens, Greece.
Jan BurmeisterFraunhofer Institute for Computer Graphics Research IGD, Darmstadt, Germany.
Thorsten MayFraunhofer Institute for Computer Graphics Research IGD, Darmstadt, Germany.
Manuel Marcelino PérezATOS, Madrid, Spain.
Iryna LishchukInstitute of Legal Informatics, Leibniz Universität Hannover, Hannover, Germany.
Thymios ChondrogiannisInstitute of Communication and Computer Systems, School of Electrical and Computer Engineering, National and Technical University of Athens, Athens, Greece.
Vassiliki AndronikouInstitute of Communication and Computer Systems, School of Electrical and Computer Engineering, National and Technical University of Athens, Athens, Greece.
Theodora VarvarigouInstitute of Communication and Computer Systems, School of Electrical and Computer Engineering, National and Technical University of Athens, Athens, Greece.
Nenad FilipovicBioengineering Research and Development Center, Faculty of Engineering, University of Kragujevac, Kragujevac, Serbia.
Manolis TsiknakisBiomedical Informatics and eHealth Laboratory, Dept. of Electrical and Computer Engineering, Hellenic Mediterranean University, Heraklion, Greece.
Chiara BaldiniDept. of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Michele BombardieriCentre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London and Barts' Health NHS Trust, London, United Kingdom.
Hendrika BootsmaDept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, the Netherlands.
Simon J BowmanRheumatology Dept., University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Muhammad Shahnawaz SoyfooDept. of Rheumatology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Dorian ParisisLaboratory of Pathophysiological Biochemistry and Nutrition, Université Libre de Bruxelles, Brussels, Belgium.
Christine DelporteLaboratory of Pathophysiological Biochemistry and Nutrition, Université Libre de Bruxelles, Brussels, Belgium.
Valérie Devauchelle-PensecUniv Brest, Inserm, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Brest, France.
Jacques-Olivier PersUniv Brest, Inserm, CHU de Brest, UMR1227, Lymphocytes B et Autoimmunité, Brest, France.
Thomas DörnerDept. of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Elena BartoloniRheumatology Unit, Dept. of Medicine and Surgery, University of Perugia, Perugia, Italy.
Roberto GerliRheumatology Unit, Dept. of Medicine and Surgery, University of Perugia, Perugia, Italy.
Roberto GiacomelliDivision of Rheumatology, Dept. of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Roland JonssonDept. of Clinical Science, University of Bergen, Bergen, Norway.
Wan-Fai NgInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Roberta PrioriDept. of Internal Medicine and Medical Specialties, Rheumatology Clinic, Sapienza University of Rome, Rome, Italy.
Manuel Ramos-CasalsLaboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Barcelona, Spain.
Kathy SivilsOklahoma Medical Research Foundation, OK, US.
Fotini SkopouliInstitute for Systemic Autoimmune and Neurological Diseases, Athens, Greece.
Witte TorstenDept. of Rheumatology and Immunology, Hanover Medical School, Hanover, Germany.
Joel A G van RoonDept. of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Mariette XavierDept. of Rheumatology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Paris, France.
Salvatore De VitaClinic of Rheumatology, Dept. of Medical and Biological Sciences, Udine University, Udine, Italy.
Athanasios G TzioufasDept. of Pathophysiology, School of Medicine, University of Athens, Athens, Greece.
Dimitrios I FotiadisUnit of Medical Technology and Intelligent Information Systems, Dept. of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
National and Kapodistrian University of Athens · GRUniversity of Ioannina · GRUniversité Libre de Bruxelles · BEAtos (Spain) · ESFraunhofer Institute for Computer Graphics Research · DEInserm · FRNeurological Institute of Athens · GRUniversity of Perugia · ITUniversity of Udine · ITAssistance Publique – Hôpitaux de Paris · FRCentre for Research and Technology Hellas · GRCharité - Universitätsmedizin Berlin · DEHellenic Mediterranean University · GRIonian University · GRLeibniz University Hannover · DEMedizinische Hochschule Hannover · DENewcastle University · GBOklahoma Medical Research Foundation · USQueen Mary University of London · GBSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For many decades, the clinical unmet needs of primary Sjögren's Syndrome (pSS) have been left unresolved due to the rareness of the disease and the complexity of the underlying pathogenic mechanisms, including the pSS-associated lymphomagenesis process. Here, we present the HarmonicSS cloud-computing exemplar which offers beyond the state-of-the-art data analytics services to address the pSS clinical unmet needs, including the development of lymphoma classification models and the identification of biomarkers for lymphomagenesis. The users of the platform have been able to successfully interlink, curate, and harmonize 21 regional, national, and international European cohorts of 7,551 pSS patients with respect to the ethical and legal issues for data sharing. Federated AI algorithms were trained across the harmonized databases, with reduced execution time complexity, yielding robust lymphoma classification models with 85% accuracy, 81.25% sensitivity, 85.4% specificity along with 5 biomarkers for lymphoma development. To our knowledge, this is the first GDPR compliant platform that provides federated AI services to address the pSS clinical unmet needs.

Indexed as

BiomarkersData curationData harmonizationData sharingFederated AILymphoma classificationPrimary Sjögren’s syndrome

Identifiers

PMID35070169
PMCPMC8760551
OpenAlexW4206561327

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.