Evidence map›Paper›PMID 35070045›Full record

ArticleWorld journal of gastrointestinal oncology2021

MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos.

Loraine Kay D Cabral, Cynthia A Mapua, Filipinas F Natividad, Caecilia H C Sukowati, Edgardo R Cortez, Ma Luisa D Enriquez

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Loraine Kay D CabralResearch and Biotechnology Group, St. Luke's Medical Center, Quezon City 1112, Philippines.
Cynthia A MapuaResearch and Biotechnology Group, St. Luke's Medical Center, Quezon City 1112, Philippines.
Filipinas F NatividadResearch and Biotechnology Group, St. Luke's Medical Center, Quezon City 1112, Philippines.
Caecilia H C SukowatiCentro Studi Fegato, Fondazione Italiana Fegato ONLUS, Trieste 34149, Italy.
Edgardo R CortezDepartment of Surgery, St. Luke's Medical Center, Quezon City 1112, Philippines.
Ma Luisa D EnriquezResearch and Biotechnology Group, St. Luke's Medical Center, Quezon City 1112, Philippines.
St. Luke's Medical Center · PHFondazione Italiana Fegato · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) ranks third in terms of incidence and second in mortality worldwide. In CRC, the silencing of mismatch repair genes, including the mutL homolog 1 (

aimTo investigate the significance of the MSI status and

methodsFifty-four sporadic CRC patients with complete clinical data were included in this study. Genomic DNA from CRC tumor biopsies and their normal tissue counterparts were profiled for MSI by high resolution melting (HRM) analysis using the Bethesda Panel of Markers (BAT25, BAT26, D2S123, D5S346, and D17S250).

results

conclusionThis study showed the clinical significance of

Indexed as

Colorectal cancerDNA methylationMicrosatellite instabilityPopulation geneticSporadic colorectal cancer

Identifiers

PMID35070045
PMCPMC8713326
OpenAlexW4200588064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.