Evidence map›Paper›PMID 35069965›Full record

ArticleKidney cancer journal : official journal of the Kidney Cancer Association2020

Dissecting the role of lymphadenectomy in the management of renal cell carcinoma: past, present, and future.

Alain Kaldany, Zev R Leopold, Juliana E Kim, Hiren V Patel, Arnav Srivastava, Alexandra L Tabakin, Eric A Singer

Abstract read
In one paragraph

Article in Kidney cancer journal : official journal of the Kidney Cancer Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alain KaldanyRutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Zev R LeopoldRutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Juliana E KimRutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Hiren V PatelRutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Arnav SrivastavaRutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Alexandra L TabakinRutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
Eric A SingerRutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
NCI NIH HHS P30 CA072720
6 · The paper itself

Abstract

Lymph node involvement in renal cell carcinoma (RCC) portends a poor prognosis. However, the role of lymph node dissection (LND) at the time of tumor resection is not fully understood. Conflicting data have been published regarding the survival implications of LND during RCC surgery, and the optimal patient population for which LND might be beneficial has yet to be identified. Based on recent data characterizing the outcomes of node-positive RCC, some have advocated for revising the current staging guidelines to better reflect these findings. Given the paucity of high-quality evidence supporting or refuting the routine use of LND in RCC, further research is needed to shed light on this important topic. There are a number of ongoing clinical trials evaluating the role of perioperative (neoadjuvant and adjuvant) systemic therapy, which include patients with node-positive RCC, and will serve to guide changes in treatment practices for this patient population moving forward.

Indexed as

kidney cancerlymphadenectomylymph node dissectionRenal Cell Carcinomasurvival

Identifiers

PMID35069965
PMCPMC8772661

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.