ReviewExperimental and therapeutic medicine2022
Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches (Review).
Review in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06918847 (Comparative Effectiveness of Myofacial Release vs Cupping Therapy on Quality of Life in Restless Leg Syndrome With Knee O.A.A RCT), which is not on this map. Cited by 34 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effectiveness of Myofacial Release vs Cupping Therapy on Quality of Life in Restless Leg Syndrome With Knee O.A.A RCT
Who cites it
34 citing papers in PubMed, 6 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Prevalence of restless legs syndrome in Pakistan: a systematic review and meta-analysis across diverse study populations.BMC neurology · 2026Pooled it
- Restless legs syndrome as a comorbidity in amyotrophic lateral sclerosis: a systematic review and meta-analysis.BMC neurology · 2025Pooled it
- The association between restless legs syndrome and chronic venous insufficiency: a systematic review.Journal of medicine and life · 2025Pooled it
- Pooled it
- Effects of Dietary Supplementation in Patients with Restless Legs Syndrome: A Systematic Review.Nutrients · 2024Pooled it
- Restless Legs Syndrome in Chronic Kidney Disease- a Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Pooled it
- Biopsychosocial barriers and facilitators in the everyday lives of patients with restless legs syndrome: a qualitative study.Annals of medicine · 2026Article
- Irritable bowel syndrome and restless legs syndrome: a narrative review of epidemiological and pathophysiological overlap.Annals of medicine and surgery (2012) · 2026Review
- Restless legs syndrome in pregnancy: Frequency, sleep quality, and questionnaire-defined risk of obstructive sleep apnea syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Adherence to positive airway pressure therapy in patients with comorbid restless legs syndrome and obstructive sleep apnea: a retrospective cohort study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Severity of restless leg syndrome in patients undergoing hemodialysis: assessing its burden on quality of life and knowledge.Frontiers in nephrology · 2026Article
- Restless legs syndrome among third-trimester pregnant women attending ANC Clinic in public hospitals in North Wollo Zone, Ethiopia.PloS one · 2026Article
- Restless legs syndrome and inflammatory bowel disease: A systematic review and meta-analysis.IBRO neuroscience reports · 2025Article
- Prevalence and Clinical Impact of Restless Legs Syndrome in Pediatric Populations with Attention-Deficit/Hyperactivity Disorder: A Systematic Review.Clocks & sleep · 2025Review
- Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.Food science & nutrition · 2025Article
- Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- Prevalence of restless leg syndrome and cutaneous manifestations among nondialysis dependent chronic kidney disease patients.Journal of education and health promotion · 2025Article
- No association between obstructive sleep apnea and restless legs syndrome: results from a large hospital-based cross-sectional study.Frontiers in sleep · 2025Article
- Restless Legs Syndrome Patients with Early Onset Disease or a Relevant Family History Associated with Pramipexole Ineffectiveness but Not Pregabalin.Nature and science of sleep · 2025Article
- Hydrotherapy and acupressure in restless legs syndrome: results of a randomized, controlled, three-armed, pilot study (HYDRAC-study).Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this overview was to outline the pathophysiology, common comorbidities and current therapeutic modalities in the treatment/management of restless legs syndrome (RLS) a sensorimotor neurological disorder. The main symptom in RLS is a compelling compulsion to move the legs and a sense of restlessness at rest most commonly occurring during the night and improving with movement. The prevalence of secondary RLS among comorbid conditions such as idiopathic pulmonary fibrosis, end-stage renal disease, irritable bowel syndrome and attention deficit/hyperactivity disorder have further elucidated our understanding of the role of the iron-dopamine hypothesis as an etiopathogenetic hallmark in RLS and the efficacy of therapeutic approaches in milder to more severe forms. Currently, RLS treatment uses only symptomatic agents, since a disease-modifying therapy does not yet exist. The phenomena of rebound and augmentation have become central phenomena in overcoming the pharmacotherapeutic challenges when treating with dopaminergic agents in RLS. Considering alternative nonpharmacological therapies, especially for the treatment of RLS in pregnancy has a significant role and positive clinical outcome for patients in controlling symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.