Evidence map›Paper›PMID 35069857›Full record

ReviewExperimental and therapeutic medicine2022

Lung neuroendocrine tumors: A systematic literature review (Review).

Cornel Savu, Alexandru Melinte, Camelia Diaconu, Ovidiu Stiru, Florentina Gherghiceanu, Ștefan Dragoș Octavian Tudorica, Oana Clementina Dumitrașcu, Angelica Bratu, Irina Balescu, Nicolae Bacalbasa

Open access · diamondAbstract readReview
In one paragraph

Review in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Neuroendocrine neoplasms of the lung: The latest updates.World journal of clinical oncology · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Cornel SavuDepartment of Thoracic Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Alexandru MelinteDepartment of Thoracic Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Camelia DiaconuDepartment of Internal Medicine, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Ovidiu StiruDepartment of Cardiovascular Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Florentina GherghiceanuDepartment of Marketing and Medical Technology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Ștefan Dragoș Octavian TudoricaDepartment of Anesthesiology and Intensive Care, Emergency University Hospital, 050098 Bucharest, Romania.
Oana Clementina DumitrașcuDepartment of Anesthesiology and Intensive Care, Emergency University Hospital, 050098 Bucharest, Romania.
Angelica BratuDepartment of Anesthesiology and Intensive Care, Emergency University Hospital, 050098 Bucharest, Romania.
Irina BalescuDepartment of Surgery, 'Ponderas' Academic Hospital, 021188 Bucharest, Romania.
Nicolae BacalbasaDepartment of Obstetrics and Gynecology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROEmergency University · USClinical Emergency Hospital Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine tumors (NETs) can have multiple localizations in the human body however, most often, it appears in the in thorax at tracheobronchial tree and the thymus. NETs are a group of tumors with heterogenous malignancy that evolve from neuroendocrine cells, with the lung being the second target organ after the gastrointestinal tract. These rare tumors are usually asymptomatic and non-functional with little information regarding incidence in the specialty literature. The main purpose of this review, was the analysis of the available literature in all aspects while mainly focusing on molecular diagnosis data and secondly, by using this molecular landscape to establish a differentiation of lung neuroendocrine tumors (LNETs). By analyzing the literature, new data were revealed regarding histological evaluation, genetic aberrations, prognosis depending on the type of LNET and therapeutic options that derive from these. Efficient management of these tumors is essential in the handling of symptoms and increase in life expectancy, especially in patients with functional tumors. Histological differentiation of LNETs is important in establishing proper therapeutic options and prognosis. Combined types of LNETs remain a controversial topic of discussion regarding diagnosis and treatment, a topic on which further studies are required in order to improve diagnosis in this group of tumors with heterogenous malignancy.

Indexed as

atypical carcinoidlarge cell neuroendocrine cancerlung neuroendocrine tumorssmall cell lung cancertypic carcinoid

Identifiers

PMID35069857
PMCPMC8764574
OpenAlexW4205486181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.