Evidence map›Paper›PMID 35069823›Full record

ArticleExperimental and therapeutic medicine2022

MicroRNA-126 and VEGF enhance the function of endothelial progenitor cells in acute myocardial infarction.

Ying Zhang, Yi Xu, Ke Zhou, Guoying Kao, Jun Xiao

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ying ZhangDepartment of Cardiovascular Medicine, Chongqing Emergency Medical Center (Fourth People's Hospital of Chongqing), Chongqing 400014, P.R. China.
Yi XuDepartment of Cardiovascular Medicine, Chongqing Emergency Medical Center (Fourth People's Hospital of Chongqing), Chongqing 400014, P.R. China.
Ke ZhouDepartment of Cardiovascular Medicine, Chongqing Emergency Medical Center (Fourth People's Hospital of Chongqing), Chongqing 400014, P.R. China.
Guoying KaoDepartment of Cardiovascular Medicine, Chongqing Emergency Medical Center (Fourth People's Hospital of Chongqing), Chongqing 400014, P.R. China.
Jun XiaoDepartment of Cardiovascular Medicine, Chongqing Emergency Medical Center (Fourth People's Hospital of Chongqing), Chongqing 400014, P.R. China.
Chongqing Emergency Medical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies have found that microRNA-126 (miR-126) overexpression can exert beneficial effects on endothelial function and angiogenesis. The role of miR-126 was previously reported to be by directly limiting the activities of negative regulators of the vascular endothelial growth factor (VEGF) pathway, such as PI3K regulation subunit 2 (PIK3R2). The aim of the present study was to investigate the role of the miR-126/PIK3R2/VEGF axis in endothelial progenitor cells (EPCs) under hypoxic conditions. An

Indexed as

acute myocardial infarctionendothelial progenitor cellsmicroRNA-126PI3K regulation subunit 2vascular endothelial growth factor

Identifiers

PMID35069823
PMCPMC8756429
OpenAlexW4200569845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.