Evidence map›Paper›PMID 35069818›Full record

ReviewExperimental and therapeutic medicine2022

Diagnostic methods for the etiological assessment of infectious corneal pathology (Review).

Mihail Zemba, Otilia-Maria Dumitrescu, Andreea-Elena Dimirache, Daniel Constantin Branisteanu, Florian Balta, Marian Burcea, Andreea Dana Moraru, Sinziana Gradinaru

Open access · diamondAbstract readReview
In one paragraph

Review in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Acanthamoeba keratitis: from pathophysiology to prevention, a contemporary clinical perspective.Medical hypothesis, discovery & innovation ophthalmology journal · 2025
    Review
  5. Review
  6. Review
  7. In the eye of the ophthalmologist: the corneal microbiome in microbial keratitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. An Unnamed Human OralCase reports in ophthalmological medicine · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mihail ZembaDepartment of Ophthalmology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Otilia-Maria DumitrescuDepartment of Ophthalmology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Andreea-Elena DimiracheDepartment of Ophthalmology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010825 Bucharest, Romania.
Daniel Constantin BranisteanuDepartment of Ophthalmology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
Florian BaltaDepartment of Ophthalmology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Marian BurceaDepartment of Ophthalmology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Andreea Dana MoraruDepartment of Ophthalmology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.
Sinziana GradinaruDepartment of Ophthalmology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROGrigore T. Popa University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious keratitis is a leading cause of visual morbidity, including blindness, all across the globe, especially in developing countries. Prompt and adequate treatment is mandatory to maintain corneal integrity and to recover the best possible final visual acuity. Although in most of the cases practitioners chose to employ empirical broad-spectrum antimicrobial medication that is usually effective, in some instances, they face the need to identify the causative agent to establish the appropriate therapy. An extensive search was conducted on published literature before December 2020 concerning the main laboratory investigations used to identify the microbial agents found in infectious keratitis, their indications, advantages, and disadvantages, as well as the results reported by other studies concerning different diagnostic tools. At present, the gold standard for diagnosis is still considered to be the isolation of microorganisms in cultures, along with the examination of smears, but other newer techniques, such as polymerase chain reaction (PCR), next-generation sequencing (NGS), and

Indexed as

Acanthamoeba keratitisbacterial keratitiscorneal ulcerfungal keratitisinfectious keratitisin vivo confocal microscopynext-generation sequencingpolymerase chain reaction

Identifiers

PMID35069818
PMCPMC8756399
OpenAlexW4200160466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.