Evidence map›Paper›PMID 35069812›Full record

ArticleTherapeutic advances in musculoskeletal disease2022

An oleuropein-based dietary supplement may improve joint functional capacity in older people with high knee joint pain: findings from a multicentre-RCT and

Marie-Noëlle Horcajada, Maurice Beaumont, Nicolas Sauvageot, Laure Poquet, Madleen Saboundjian, Berenice Costes, Peter Verdonk, Geoffrey Brands, Jean Brasseur, Didier Urbin-Choffray and 8 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in musculoskeletal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
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  3. REJENERAInflammopharmacology · 2026
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  4. A comprehensive review ofRSC advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 2 countries.

Marie-Noëlle HorcajadaMusculoskeletal Health Department, Nestle Research, EPFL Innovation Park, 1015 Lausanne, Switzerland.
Maurice BeaumontNestle Research, Vers-chez-les-Blanc, Lausanne, Switzerland.
Nicolas SauvageotNestle Research, Vers-chez-les-Blanc, Lausanne, Switzerland.
Laure PoquetNestle Research, EPFL Innovation Park, Lausanne, Switzerland.
Madleen SaboundjianNestle Research, EPFL Innovation Park, Lausanne, Switzerland.
Berenice CostesArtialis SA, CHU Sart-Tilman, Liège, Belgium.
Peter VerdonkAntwerpen Orthopedic Center, Antwerpen, Belgium.
Geoffrey BrandsCHC, Clinique Saint-Joseph, Liège, Belgium.
Jean BrasseurCHU UCL Namur, Site Mont-Godinne, Yvoir, Belgium.
Didier Urbin-ChoffrayCentre Hospitalier Régional de la Citadelle, Liège, Belgium.
Marc VandenbergheGrand Hôpital de Charleroi, Charleroi, Belgium.
Karl BrabantsZNA Middelheim, Antwerpen, Belgium.
Kurt De VlamZNA Jan Palfijn, Merksem, Belgium.
Werner FacheLinus Pauling Preventie Centrum, Gent, Belgium.
Bernard JandrainClinical Pharmacology Unit, ATC S.A., Liège, Belgium.
Vincent Grek2B Clinic, Wavre, Belgium.
Michel MalaiseCHU Sart-Tilman, Liège, Belgium.
Yves HenrotinmusculoSKeletal Innovative research Lab (mSKIL), The Center for Interdisciplinary Research on Medicines (CIRM), Department of Motricity Center, Institute of Pathology, University of Liège, CHU Sart-Tilman, 4000 Liège, Belgium; Artialis SA, CHU Sart-Tilman, Liège, Belgium; Department of Physical Therapy and Rehabilitation, Princess Paola Hospital, Vivalia, Marche-en-Fammenne, Belgium.ORCID https://orcid.org/0000-0003-1073-449X
Nestlé (Switzerland) · CHAbbott (Belgium) · BEAZ Sint-Jan · BECentre hospitalier régional de la Citadelle · BECentre Hospitalier Universitaire de Liège · BECHU Dinant Godinne UCL Namur · BEClinique Saint-Joseph · BEGrand Charleroi Hospital · BEProvince of Antwerp · BEUniversity of Liège · BEZNA Middelheim Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate a 6-month intervention with an olive leaf extract (OLE) on knee functionality and biomarkers of bone/cartilage metabolism and inflammation.

designThis randomized, double-blind, placebo-controlled, multi-centric trial included 124 subjects with knee pain or mobility issues. Subjects received twice a day one capsule of placebo or 125 mg OLE (Bonolive

resultsAt 6 months, OLE group was not efficient on global KOOS score, changes of inflammatory and cartilage remodeling biomarkers compared to placebo.

conclusionOLE was not effective on joint discomfort excepted in a sub-group of subjects with high pain at treatment initiation. As oleuropein is well tolerated, OLE can be used to relieve knee joint pain and enhance mobility in subjects with articular pain.

Indexed as

functionjoint painnutritional supplementoleuropein

Identifiers

PMID35069812
PMCPMC8777337
OpenAlexW4205086977

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.