Evidence map›Paper›PMID 35069758›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2022

Molecular Mechanism of Traditional Chinese Ointment of Xuzhou Qufu Shengji in Infected Wounds.

Jinhu Shen, Chaoding Li, Lei Zhang, Yan Sun, Lin Zhang, Liuzhong Yang

RetractedOpen access · hybridAbstract readRetracted Publication
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jinhu ShenDepartment of Orthopedics, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou 221004, Jiangsu, China.
Chaoding LiDepartment of Orthopedics, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou 221004, Jiangsu, China.
Lei ZhangDepartment of Orthopedics, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou 221004, Jiangsu, China.
Yan SunDepartment of Orthopedics, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou 221004, Jiangsu, China.
Lin ZhangDepartment of the First Clinical Medicine, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China.
Liuzhong YangDepartment of Orthopedics, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou 221004, Jiangsu, China.ORCID https://orcid.org/0000-0002-5228-9761
Xuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundXuzhou Qufu Shengji Ointment (QFSJO) has been used in hospital and private medication for more than 30 years to treat the infective wounds after trauma. However, molecular investigation is lacking. This study used rats to explore the healing mechanism of QFSJO in promoting wound healing in human.

methodsOne circular incision was individually generated on the back of 30 rats in three groups and challenged with 10

resultsA faster wound healing ratio was observed in QFSJO-dressing-treated group than Vaseline- and erythrocin-treated groups. ELISA results showed that QFSJO promoted VEGF and b-FGF levels significantly in early stage of wound healing. QFSJO dressing group also showed an enhanced hydroxyproline and hemoglobin in granulation tissue. The expressions of CD31 and CD34 in granulation tissue of QFSJO group were higher than in the Vaseline and erythrocin groups.

conclusionQFSJO improved the healing rate of the infective wounds by promoting the angiogenesis of granulation tissue and inhibiting the inflammation of the trauma tissue. Our finding suggests that QFSJO is able to help angiogenic capillary sprouts for collagen accumulates in the granulation tissue.

Identifiers

PMID35069758
PMCPMC8769828
OpenAlexW4205196403

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.