ArticleFrontiers in immunology2021
Obesity Increases Gene Expression of Markers Associated With Immunosenescence in Obese Middle-Aged Individuals.
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- New Mediators in the Crosstalk between Different Adipose Tissues.International journal of molecular sciences · 2024Pooled it
- Does sex moderate health and Alzheimer's disease risk tied to early educational experiences? The reducing inequities through social and educational change follow-up in early adulthood extension study protocol.Brain, behavior, & immunity - health · 2026Article
- Lifelong Exercise as a Modulator of CD4European journal of clinical investigation · 2026Review
- AdultBiomolecules · 2026Article
- Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial.Frontiers in endocrinology · 2026Article
- Metformin Inhibits Inflammation by Targeting the NLRP3 Inflammasome: Linking NF-κB/NEK7/AMPK Signaling to Mitochondrial Function.Journal of inflammation research · 2026Review
- Review
- Review
- Switching from a High-Fat to a Regular Chow Diet Improves Obesity Progression in Mice.Current issues in molecular biology · 2025Article
- Short-Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study.Aging cell · 2025Article
- Interaction between 3-SNP genetic risk score and dietary fats intake on inflammatory markers among overweight and obese women.Journal of diabetes and metabolic disorders · 2025Article
- Nutraceuticals for Gut-Brain Axis Health: A Novel Approach to Combat Malnutrition and Future Personalised Nutraceutical Interventions.Nutrients · 2025Review
- What Is the Impact of Obesity-Related Comorbidities on the Risk of Premature Aging in Patients with Severe Obesity?: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder.Molecular psychiatry · 2025Article
- Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis.Frontiers in psychiatry · 2025Article
- Accelerated biological aging as potential mediator in the relationship between central obesity and lung cancer risk.Frontiers in aging · 2025Article
- Single Nuclei Transcriptomics Reveals Obesity-Induced Endothelial and Neurovascular Dysfunction: Implications for Cognitive Decline.International journal of molecular sciences · 2024Article
- T-Cell Senescence in Human Metabolic Diseases.Diabetes & metabolism journal · 2024Review
- Oxidative Stress Responses in Obese Individuals Undergoing Bariatric Surgery: Impact on Carcinogenesis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- The Immune Response ofInternational journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, it has been argued that obesity leads to a chronic pro-inflammatory state that can accelerate immunosenescence, predisposing to the early acquisition of an immune risk profile and health problems related to immunity in adulthood. In this sense, the present study aimed to verify, in circulating leukocytes, the gene expression of markers related to early immunosenescence associated with obesity and its possible relationships with the physical fitness in obese adults with type 2 diabetes or without associated comorbidities. The sample consisted of middle-aged obese individuals (body mass index (BMI) between 30-35 kg/m²) with type 2 diabetes mellitus (OBD; n = 17) or without associated comorbidity (OB; n = 18), and a control group of eutrophic healthy individuals (BMI: 20 - 25 kg/m²) of same ages (E; n = 18). All groups (OBD, OB and E) performed the functional analyses [muscle strength (1RM) and cardiorespiratory fitness (VO
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.