Evidence map›Paper›PMID 35069566›Full record

ArticleFrontiers in immunology2021

Follicular Helper T-Cell-Based Classification of Endometrial Cancer Promotes Precise Checkpoint Immunotherapy and Provides Prognostic Stratification.

Yi Chen, Shuwen You, Jie Li, Yifan Zhang, Georgia Kokaraki, Elisabeth Epstein, Joseph Carlson, Wen-Kuan Huang, Felix Haglund

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. CD4Trends in cancer · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Biomarkers of tumor-reactive CD4Journal for immunotherapy of cancer · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Yi ChenDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Shuwen YouDepartment of Gynecology Oncology, Women's Hospital of Zhejiang University, Hangzhou, China.
Jie LiCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Yifan ZhangDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Georgia KokarakiDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Elisabeth EpsteinDepartment of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden.
Joseph CarlsonDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Wen-Kuan HuangDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Felix HaglundDepartment of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEKarolinska University Hospital · SEShandong University of Traditional Chinese Medicine · CNStockholm South General Hospital · SEWomen's Hospital, School of Medicine, Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the fact that management of EC is moving towards four TCGA-based molecular classifications, a pronounced variation in immune response among these molecular subtypes limits its clinical use. We aimed to investigate the determinant biomarker of ICI response in endometrial cancer (EC). We characterized transcriptome signatures associated with tumor immune microenvironment in EC. Two immune infiltration signatures were identified from the TCGA database (

Indexed as

Endometrial NeoplasmsImmunotherapyModels, ImmunologicalDisease-Free SurvivalFemaleHumansImmune Checkpoint InhibitorsLymphocytes, Tumor-InfiltratingMiddle AgedSurvival RateT-Lymphocytes, Helper-InducerImmune Checkpoint Inhibitorscomputational biologyfemalegenital neoplasmsimmunotherapytumor biomarkerstumor microenvironment

Identifiers

PMID35069566
PMCPMC8777298
OpenAlexW4206580349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.