Evidence map›Paper›PMID 35069549›Full record

ArticleFrontiers in immunology2021

The Anti-Inflammatory and Uric Acid Lowering Effects of Si-Miao-San on Gout.

Ling Cao, Tianyi Zhao, Yu Xue, Luan Xue, Yueying Chen, Feng Quan, Yu Xiao, Weiguo Wan, Man Han, Quan Jiang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Ling CaoDivision of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China.
Tianyi ZhaoDivision of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China.
Yu XueDivision of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China.
Luan XueDepartment of Rheumatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yueying ChenDepartment of Rheumatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Feng QuanDepartment of Rheumatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yu XiaoInstitute of Spacecraft Equipment, Shanghai, China.
Weiguo WanDivision of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China.
Man HanGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Quan JiangGuang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Liwei LuDepartment of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Hejian ZouDivision of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China.
Xiaoxia ZhuDivision of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China.
Huashan Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNYueyang Hospital · CNChina Academy of Space Technology · CNCity University of Hong Kong, Shenzhen Research Institute · CNFudan University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Si-Miao-San (SMS) is a well-known traditional Chinese medicine. This study aims to evaluate the anti-inflammatory effects of SMS on gouty arthritis and its potential mechanism of action. Methods: The effects and mechanism of SMS were evaluated in monosodium urate (MSU)-treated mice or macrophages. The expression of cytokines and PI3K/Akt was analyzed using real-time PCR and Western blotting analyses. Macrophage polarization was assessed with immunofluorescence assays, real-time PCR, and Western blotting. Mass spectrometry was used to screen the active ingredients of SMS. Results: Pretreatment with SMS ameliorated MSU-induced acute gouty arthritis in mice with increased PI3K/Akt activation and M2 macrophage polarization in the joint tissues. Conclusion: SMS ameliorated MSU-induced gouty arthritis and inhibited hyperuricemia. The anti-inflammatory mechanism of SMS may exert anti-inflammatory effects by promoting M2 polarization

Indexed as

GoutMacrophagesUric AcidAnimalsAnti-Inflammatory AgentsChromonesDrugs, Chinese HerbalHumansMaleMiceMorpholinesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTHP-1 Cells2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneAnti-Inflammatory AgentsChromonesDrugs, Chinese HerbalMorpholinesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktUric AcidgouthyperuricemiainflammationSi-Miao-Sanuric acid

Identifiers

PMID35069549
PMCPMC8769502
OpenAlexW4206168930

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.