Evidence map›Paper›PMID 35069485›Full record

ArticleFrontiers in microbiology2021

Insight Into the Anti-staphylococcal Activity of JBC 1847 at Sub-Inhibitory Concentration.

Troels Ronco, Line H Kappel, Maria F Aragao, Niccolo Biagi, Søren Svenningsen, Jørn B Christensen, Anders Permin, Lasse Saaby, Kim Holmstrøm, Janne K Klitgaard and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 4 countries.

Troels RoncoDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Line H KappelResearch Unit of Molecular Microbiology, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Maria F AragaoDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Niccolo BiagiDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Søren SvenningsenDepartment of Chemistry, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Jørn B ChristensenDepartment of Chemistry, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Anders PerminUnibrains, Virum, Denmark.
Lasse SaabyBioneer A/S, Hørsholm, Denmark.
Kim HolmstrømBioneer A/S, Hørsholm, Denmark.
Janne K KlitgaardResearch Unit of Molecular Microbiology, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Artur J SabatDepartment of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Viktoria AkkerboomDepartment of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Monica MonacoDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Marco TinelliDivision of Infectious and Tropical Diseases, Hospital of Lodi, Lodi, Italy.
Alexander W FriedrichDepartment of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Bimal JanaDepartment of Biology, Boston College, Chestnut Hill, MA, United States.
Rikke H OlsenDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DKBioneer (Denmark) · DKUniversity Medical Center Groningen · NLUniversity of Southern Denmark · DKBoston College · USIstituto Superiore di Sanità · ITOspedale Maggiore di Lodi · ITUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug-resistant pathogens constitute a serious global issue and, therefore, novel antimicrobials with new modes of action are urgently needed. Here, we investigated the effect of a phenothiazine derivative (JBC 1847) with high antimicrobial activity on

Indexed as

antimicrobial resistanceGram-positive bacteriamode of actionphenothiazine derivativeRNA transcriptomics

Identifiers

PMID35069485
PMCPMC8766816
OpenAlexW4206590405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.