Evidence map›Paper›PMID 35069446›Full record

ArticleFrontiers in endocrinology2021

The Role of Fatty Acid Signaling in Islet Beta-Cell Adaptation to Normal Pregnancy.

Jee-Hye Kim, Viviane Delghingaro-Augusto, Jeng Yie Chan, D Ross Laybutt, Joseph Proietto, Christopher J Nolan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jee-Hye KimAustralian National University Medical School, Australian National University, Canberra, ACT, Australia.
Viviane Delghingaro-AugustoAustralian National University Medical School, Australian National University, Canberra, ACT, Australia.
Jeng Yie ChanGarvan Institute of Medical Research, St Vincent's Clinical School, University of New South Wales (UNSW), Sydney, NSW, Australia.
D Ross LaybuttGarvan Institute of Medical Research, St Vincent's Clinical School, University of New South Wales (UNSW), Sydney, NSW, Australia.
Joseph ProiettoDepartment of Medicine (Austin Health), University of Melbourne, Heidelberg Heights, VIC, Australia.
Christopher J NolanAustralian National University Medical School, Australian National University, Canberra, ACT, Australia.
Australian National University · AUGarvan Institute of Medical Research · AUUniversity of Melbourne · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Maintenance of a normal fetal nutrient supply requires major adaptations in maternal metabolic physiology, including of the islet beta-cell. The role of lipid signaling processes in the mechanisms of islet beta-cell adaptation to pregnancy has been minimally investigated. Objective: To determine the effects of pregnancy on islet fatty acid (FA) metabolic partitioning and FA augmentation of glucose-stimulated insulin secretion (GSIS). Methods: Age matched virgin, early pregnant (gestational day-11, G11) and late pregnant (G19) Sprague-Dawley rats were studied. Fasted and fed state biochemistry, oral glucose tolerance tests (OGTT), and fasted and post-OGTT liver glycogen, were determined to assess Results: Plasma glucose in pregnancy was lower, including during the OGTT (glucose area under the curve 0-120 min (AUC Conclusion: A lowered set-point for islet and hepatic glucose homeostasis in the pregnant rat has been confirmed. Islet adaptation to pregnancy includes increased FA esterification, reduced FA oxidation, and enhanced FA augmentation of glucose-stimulated insulin secretion.

Indexed as

AnimalsBlood GlucoseEsterificationFatty AcidsFemaleGlucose Tolerance TestGlycerolGlycogenInsulin-Secreting CellsInsulin SecretionLipolysisLiverOxidation-ReductionPregnancyRatsSignal TransductionBlood GlucoseFatty AcidsGlycerolGlycogenTriglyceridesfatty acid metabolismfatty acid signalinghyperlipidemiainsulin secretionpancreatic islet beta-cellPpargc1apregnancySprague-Dawley rat

Identifiers

PMID35069446
PMCPMC8766493
OpenAlexW4205451322

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.