Evidence map›Paper›PMID 35069124›Full record

ReviewFrontiers in neural circuits2021

From Synapses to Circuits, Astrocytes Regulate Behavior.

Krissy A Lyon, Nicola J Allen

Abstract readReview
In one paragraph

Review in Frontiers in neural circuits, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Developmental changes in CaScientific reports · 2026
    Article
  2. Review
  3. Astrocyte TrkB.T1 Deficiency Disrupts Glutamatergic Synaptogenesis and Astrocyte-Synapse Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Astrocytes mediate a positive feedback loop for oxytocin.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Shaping the Neocortex: Radial Glia and Astrocytes in Development and Evolution.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  14. Article
  15. Spontaneous activity of astrocytes is a stochastic functional signal for memory consolidation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Krissy A LyonMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, United States.
Nicola J AllenMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, United States.

Funding

Unbiased Epigenomic and Transcriptomic Profiling of Non-Neuronal Cells in the Mouse BrainRF1DA048816 · NIDA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ALLEN, NICOLA J, ECKER, JOSEPH R · 2019 to 2019
$4.7M
Astrocyte regulation of neuronal AMPA glutamate receptorsR01NS089791 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ALLEN, NICOLA J · 2014 to 2023
$4.2M
Astrocyte regulation of synapse maturationR01NS105742 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ALLEN, NICOLA J · 2018 to 2022
$2.4M
Circuits, Serotonergic Neurons, and the Modulation of Behavior: Characterization of a Specialized Serotonergic Neuron Subtype Responsive to Dopamine and Central to Social BehaviorK00NS108515 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI LYON, KRISTINE ANNE · 2021 to 2024
$339k
NIDA NIH HHS RF1 DA048816NINDS NIH HHS K00 NS108515NINDS NIH HHS R01 NS089791NINDS NIH HHS R01 NS105742
6 · The paper itself

Abstract

Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior. Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes influence synapse formation, function, and plasticity. Beyond the synapse, recent research has revealed that astrocyte influences on the nervous system extend to the modulation of neuronal circuitry and behavior. Here we review recent findings on the active role of astrocytes in behavioral modulation with a focus on

Indexed as

AstrocytesSynapsesAnimalsMiceNeurogenesisNeuronsOptogeneticsastrocytebehaviorchemogeneticGPCRoptogenetic

Identifiers

PMID35069124
PMCPMC8772456

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.