Evidence map›Paper›PMID 35068860›Full record

ArticleWorld journal of gastroenterology2021

Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model.

Jia-Yi Liu, Zhu-Yuan Ding, Zi-Yi Zhou, Sheng-Zhen Dai, Jie Zhang, Hao Li, Qiu Du, Ye-Yu Cai, Quan-Liang Shang, Yong-Heng Luo and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. The Role of Tβ4-POP-Ac-SDKP Axis in Organ Fibrosis.International journal of molecular sciences · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jia-Yi LiuDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Zhu-Yuan DingDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Zi-Yi ZhouDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Sheng-Zhen DaiDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Jie ZhangDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Hao LiDepartment of Emergency Medicine, First People's Hospital of Changde City, Changde 415000, Hunan Province, China.
Qiu DuDepartment of Urology, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan Province, China.
Ye-Yu CaiDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Quan-Liang ShangDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Yong-Heng LuoDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China. luoyongheng@csu.edu.cn.
En-Hua XiaoDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBile duct ligation (BDL) in animals is a classical method for mimicking cholestatic fibrosis. Although different surgical techniques have been described in rats and rabbits, mouse models can be more cost-effective and reproducible for investigating cholestatic fibrosis. Magnetic resonance imaging (MRI) has made great advances for noninvasive assessment of liver fibrosis. More comprehensive liver fibrotic features of BDL on MRI are important. However, the utility of multiparameter MRI to detect liver fibrosis in a BDL mouse model has not been assessed.

aimTo evaluate the correlation between the pathological changes and multiparameter MRI characteristics of liver fibrosis in a BDL mouse model.

methodsTwenty-eight healthy adult male balb/c mice were randomly divided into four groups: sham, week 2 BDL, week 4 BDL, and week 6 BDL. Multiparameter MRI sequences, included magnetic resonance cholangiopancreatography, T1-weighted, T2-weighted, T2 mapping, and pre- and post-enhanced T1 mapping, were performed after sham and BDL surgery. Peripheral blood and liver tissue were collected after MRI. For statistical analysis, Student's

resultsFour mice died after BDL surgery; seven, six, five and six mice were included separately from the four groups. Signal intensities of liver parenchyma showed no difference on TI- and T2-weighted images. Bile duct volume, ΔT1 value, T2 value, and the rate of liver fibrosis increased steadily in week 2 BDL, week 4 BDL and week 6 BDL groups compared with those in the sham group (

conclusionThe BDL mouse model induces changes that can be observed on MRI. The MRI parameters correlate with the hepatic fibrosis rate and allow for detection of cholestatic fibrosis.

Indexed as

Bile DuctsLiver CirrhosisAnimalsDisease Models, AnimalLigationLiverMagnetic Resonance ImagingMaleMiceRabbitsRatsAnimal modelBile duct ligationFibrosisLiverMagnetic resonance imagingPathology

Identifiers

PMID35068860
PMCPMC8704273
OpenAlexW4200036471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.