Evidence map›Paper›PMID 35068803›Full record

ArticleJournal of clinical and experimental hepatology

Versatility of Anabolic Androgenic Steroid-Induced Hepatotoxicity.

Vaibhav Patil, Dinesh Jothimani, Kavya Harika, Abdul Rahman Hakeem, Deepti Sachan, Mukul Vij, Mohamed Rela

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Anabolic androgenic steroid-induced liver injury: An update.World journal of gastroenterology · 2022
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Vaibhav PatilInstitute of Liver disease and Transplantation, Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.
Dinesh JothimaniInstitute of Liver disease and Transplantation, Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.
Kavya HarikaInstitute of Liver disease and Transplantation, Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.
Abdul Rahman HakeemInstitute of Liver disease and Transplantation, Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.
Deepti SachanDepartment of Transfusion Medicine, Institute of Liver disease and Transplantation, Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.
Mukul VijDepartment of pathology, Institute of Liver disease and Transplantation, Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.
Mohamed RelaInstitute of Liver disease and Transplantation, Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.
Bharath University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The modified derivatives of testosterone, termed as androgenic steroids are indicated in the management of hypogonadism, visceral obesity and metabolic disorders. Anabolic androgenic steroids (AASs) however are surreptitiously used by athletes and body builders for cosmetic purpose owing to their anabolic effects on muscle mass and strength. The unsurveilled use of AASs subjects these users to various side effects involving multiple systems such as the endocrine, genitourinary, hepatobiliary, central nervous, musculoskeletal and psychosocial system. The liver is a hormone-sensitive organ owing to abundance of androgen receptors and is vulnerable to a wide array of hepatotoxicity ranging from asymptomatic liver enzyme elevation to life-threatening subacute liver failure. The type of drug-induced liver injury (DILI) due to AASs can be hepatocellular injury, cholestasis, fatty liver disease, chronic vascular injury and neoplastic disease. Herein, we report three cases of AAS-related DILI associated with AAS abuse.

Indexed as

AAS, anabolic androgenic steroidALP, alkaline phosphataseALT, alanine aminotransferaseanabolic steroidsAR, androgen receptorAST, aspartate aminotransferasecholestasisCT, computed tomographyDILIDILI, drug-induced liver injuryGGT, gamma-glutamyl transferaseHA, hepatocellular adenomaHCC, hepatocellular carcinomaHE, hepatic encephalopathyhepatocellular neoplasmHUMP, hepatocellular neoplasm of uncertain malignant potentialLDLT, living donor liver transplantationLFT, liver function testpeliosis hepatisRUCAM, Roussel Uclaf Causality Assessment MethodSALF, subacute liver failuresteatosisTACE, transarterial chemoembolizationTPE, therapeutic plasma exchange

Identifiers

PMID35068803
PMCPMC8766528
OpenAlexW3138654952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.