Evidence map›Paper›PMID 35068799›Full record

ArticleJournal of clinical and experimental hepatology

Suppression of Bile Acid Synthesis in a Preterm Infant Receiving Prolonged Parenteral Nutrition.

Naureen Memon, Chris W Lee, Aimee Herdt, Barry I Weinberger, Thomas Hegyi, Mary O Carayannopoulos, Lauren M Aleksunes, Grace L Guo, Ian J Griffin

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Fibroblast growth factor 19 secretion and function in perinatal development.American journal of physiology. Gastrointestinal and liver physiology · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Naureen MemonMidAtlantic Neonatology Associates, Morristown, NJ, USA.
Chris W LeeMidAtlantic Neonatology Associates, Morristown, NJ, USA.
Aimee HerdtMidAtlantic Neonatology Associates, Morristown, NJ, USA.
Barry I WeinbergerCohen Children's Medical Center of New York, New Hyde Park, NY, USA.
Thomas HegyiRutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Mary O CarayannopoulosRutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Lauren M AleksunesDepartment of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA.
Grace L GuoDepartment of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ, USA.
Ian J GriffinMidAtlantic Neonatology Associates, Morristown, NJ, USA.
Rutgers, The State University of New Jersey · USUrology Associates · USCohen Children's Medical Center · USGoryeb Children's Hospital · USJohnson University · US

Funding

Gut-liver crosstalk by FGF15/19 in regulating xenobiotic nuclear receptor activationR01GM135258 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, GRACE L · 2020 to 2023
$1.4M
Gut bile acids, Fxr, & Fgf15 in total parenteral nutrition-associated cholestasisR01GM104037 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, GRACE L · 2013 to 2016
$1.1M
NIGMS NIH HHS R01 GM104037NIGMS NIH HHS R01 GM135258
6 · The paper itself

Abstract

Bile acid metabolism is altered in neonates on parenteral nutrition (PN), predisposing them to parenteral nutrition-associated liver disease. Cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the bile acid synthesis pathway, is repressed by fibroblast growth factor 19 (FGF19) and phytosterols (PS). We describe a case of a preterm infant who developed necrotizing enterocolitis (NEC) and received exclusive PN for over 2 months. Our objective was to serially assess CYP7A1 activity and plasma FGF19 and PS concentrations in this infant case compared to five healthy preterm infants. We found that CYP7A1 activity increased during the first 2 weeks of life in control infants but was undetectable in the infant case. FGF19 concentrations were high at birth in all infants and subsequently declined and did not differ between the case and control infants. As expected, PS concentrations were elevated in the infant case and continued to increase despite lipid minimization. In conclusion, CYP7A1 activity was gradually upregulated in healthy preterm infants but remained suppressed in the infant requiring prolonged PN. Preterm infants also had elevated FGF19 concentrations at birth, which decreased with advancing postnatal age.

Indexed as

ALT, alanine aminotransferaseAST, aspartate aminotransferaseBA, bile acidbile acid metabolismC4, 7α-hydroxy-4-cholestene-3-onecholesterol 7-alpha hydroxylaseCYP7A1, cholesterol 7α-hydroxylaseDMG, N, N-dimethylglycineDOL, day of lifeELISA, enzyme-linked immunosorbent assayfarnesoid x receptorFGF19, fibroblast growth factor 19fibroblast growth factor 19FXR, Farnesoid X receptorintravenous lipid emulsionIRB, institutional review boardLC-MS/MS, liquid chromatography/tandem mass spectrometryNEC, necrotizing enterocolitisNPO, nil per osPNALD, parenteral nutrition-associated liver diseasePN, parenteral nutritionPS, phytosterols

Identifiers

PMID35068799
PMCPMC8766543
OpenAlexW3153326332

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.