Evidence map›Paper›PMID 35068790›Full record

ArticleJournal of clinical and experimental hepatology

Early Allograft Dysfunction After Live Donor Liver Transplantation: It's Time to Redefine?

Viniyendra Pamecha, Bramhadatta Pattnaik, Piyush K Sinha, Nilesh S Patil, Shridhar V Sasturkar, Nihar Mohapatra, Guresh Kumar, Ashok Choudhury, Shiv K Sarin

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In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Viniyendra PamechaDepartment of Liver Transplant and Hepato-Pancreato-Biliary Surgery, Institute of Liver & Biliary Sciences, New Delhi, India.
Bramhadatta PattnaikDepartment of Liver Transplant and Hepato-Pancreato-Biliary Surgery, Institute of Liver & Biliary Sciences, New Delhi, India.
Piyush K SinhaDepartment of Liver Transplant and Hepato-Pancreato-Biliary Surgery, Institute of Liver & Biliary Sciences, New Delhi, India.
Nilesh S PatilDepartment of Liver Transplant and Hepato-Pancreato-Biliary Surgery, Institute of Liver & Biliary Sciences, New Delhi, India.
Shridhar V SasturkarDepartment of Liver Transplant and Hepato-Pancreato-Biliary Surgery, Institute of Liver & Biliary Sciences, New Delhi, India.
Nihar MohapatraDepartment of Liver Transplant and Hepato-Pancreato-Biliary Surgery, Institute of Liver & Biliary Sciences, New Delhi, India.
Guresh KumarDepartment of Biostatistics, Institute of Liver & Biliary Sciences, New Delhi, India.
Ashok ChoudhuryDepartment of Hepatology, Institute of Liver & Biliary Sciences, New Delhi, India.
Shiv K SarinDepartment of Hepatology, Institute of Liver & Biliary Sciences, New Delhi, India.
Institute of Liver and Biliary Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn ideal definition of early allograft dysfunction (EAD) after live donor liver transplantation (LDLT) remains elusive. The aim of the present study was to compare the diagnostic accuracies of existing EAD definitions, identify the predictors of early graft loss due to EAD, and formulate a new definition, estimating EAD-related mortality in LDLT recipients.

methodsConsecutive adult patients undergoing elective LDLT were analyzed. Patients with technical (vascular, biliary) complications and biopsy-proven rejections were excluded.

resultsThere were 19 deaths due to EAD of a total of 304 patients. On applying the existing definitions of EAD, we revealed their limitations of being either too broad with low specificity or too restrictive with low sensitivity in patients with LDLT. A new definition of EAD-LDLT (total bilirubin >10 mg/dL, international normalized ratio [INR] > 1.6 and serum urea >100 mg/dL, for five consecutive days after day 7) was derived after doing a multivariate analysis. In receiver operator characteristics analysis, an AUC for EAD-LDLT was 0.86. The calibration and internal cross-validation of the new model confirmed its predictability.

conclusionThe new model of EAD-LDLT, based on total bilirubin >10 mg/dL, INR >1.6 and serum urea >100 mg/dL, for five consecutive days after day 7, has a better predictive value for mortality due to EAD in LDLT recipients.

Indexed as

AUC, area under curveCIT, cold ischemia timeDDLT, deceased donor liver transplantationDFH, delayed functional hyperbilirubinemiaEAD, early allograft dysfunctiongraft dysfunctionGRWR, graft-to-recipient weight ratioHDU, high dependency unithyperbilirubinemiaICU, intensive care unitINR, international normalized ratiointernational normalized ratioIR, ischemia-reperfusionLDLT, living donor liver transplantationliving donor liver transplantationMELD, model for end-stage liver diseaseMHV, middle hepatic veinPGD, primary graft dysfunctionPNF, primary non-functionPOD, postoperative dayPPV, positive predictive valueROC, receiver operator characteristicsSFSS, small for size syndromeurea

Identifiers

PMID35068790
PMCPMC8766541
OpenAlexW3147209082

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.