ArticleJournal of clinical and experimental hepatology
European Working Group on Sarcopenia in Older People (EWGSOP2) Criteria With Population-Based Skeletal Muscle Index Best Predicts Mortality in Asians With Cirrhosis.
Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Prognostic value of different sarcopenia assessment methods for mortality in patients with liver cirrhosis: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Comparison of the Risk of Early Postoperative Infection and Length of Hospital Stay between Sarcopenic and Nonsarcopenic Adults Undergoing Live Donor Liver Transplantation Using Computed Tomography.The Indian journal of radiology & imaging · 2026Article
- Identifying Individuals at Risk of Functional Decline Despite Preserved Muscle Mass: Insights from Appendicular Skeletal Muscle Mass and Handgrip Strength Discordance.Journal of clinical medicine · 2026Article
- Beyond Handgrip: Associations Between Trunk Strength, Gait Speed, Resting Metabolic Rate, and Muscle Mass in Brazilian Older Women with Probable Sarcopenia.International journal of environmental research and public health · 2026Article
- Hierarchical Evaluation of Predictive Models for Confirmed Sarcopenia: Discrimination, Calibration, and Clinical Applicability in a Cross-Sectional Study of Older Adults.Journal of clinical medicine · 2025Article
- Multimodal ultrasound in the assessment of muscle involvement in systemic sclerosis patients: results from a bicentric study.Rheumatology (Oxford, England) · 2025Article
- Prevalence of Sarcopenia Among Slovenian Older Adults and Associated Risk Factors.Zdravstveno varstvo · 2025Article
- Low appendicular skeletal muscle mass is associated with the risk of mortality among adults in the United States.Scientific reports · 2025Article
- Prevention of Sarcopenia.Advances in experimental medicine and biology · 2025Review
- Aromatase inhibitor-induced bone loss osteosarcopenia in older patients with breast cancer: effects of the RANK/RANKL system's inhibitor denosumab vs. bisphosphonates.Internal and emergency medicine · 2024Article
- Quantitative Assessment of Body Composition in Cirrhosis.Diagnostics (Basel, Switzerland) · 2024Review
- Sarcopenia evaluated by EASL/AASLD computed tomography-based criteria predicts mortality in patients with cirrhosis: A systematic review and meta-analysis.JHEP reports : innovation in hepatology · 2024Article
- Serum zinc concentration as a potential predictor of presarcopenia in patients with chronic liver disease: a preliminary study.Translational gastroenterology and hepatology · 2024Article
- Osteosarcopenia in NAFLD/MAFLD: An Underappreciated Clinical Problem in Chronic Liver Disease.International journal of molecular sciences · 2023Review
- Prevalence of sarcopenia in older women and level of agreement between the diagnostic instruments proposed by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2).BMC musculoskeletal disorders · 2023Article
- Liver cirrhosis and sarcopenia: a dreadful combination.Hepatobiliary surgery and nutrition · 2022Article
- Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19.Diagnostics (Basel, Switzerland) · 2022Article
- Assessment of Sarcopenia in Chronic Liver Disease: Indian Perspective.Clinical liver disease · 2021Review
- Impact of Sarcopenia on Survival and Clinical Outcomes in Patients With Liver Cirrhosis.Frontiers in nutrition · 2021Article
- May Skeletal Muscle Index Predict Mortality in Individuals with Cirrhosis?Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsMultiple definitions of sarcopenia exist and the acceptable criterion that best predicts outcome is lacking. We estimated the prevalence of sarcopenia based on four criteria and assessed their utility in predicting mortality in cirrhotics.
methodsIn a prospective observational study, consecutive Asian patients with cirrhosis underwent testing for handgrip strength (HGS) and estimation of skeletal muscle index (SMI) using computed tomography at the third lumbar vertebra. Sarcopenia was defined based on the Western cut-off (WC; SMI < 50 cm
resultsWe included 219 patients with cirrhosis (168 men; mean age 42.6 years) with 50.2% patients having decompensation. Alcohol was the commonest aetiology (33.3%). The prevalence of sarcopenia was highest with the WC (men: 82.1%; women: 62.7%). There was a weak concordance among all criteria (Fleiss' kappa 0.23, 95% confidence interval [CI] 0.10-0.37). Overall, 12-month survival was 86.1% (81.1-91.3%) over a median (interquartile range) follow-up of 12 (6-15) months. Ascites (hazards ratio [HR] 6.27 [95% CI 1.6-24.1];
conclusionA weak concordance exists amongst various diagnostic definitions of sarcopenia. Sarcopenia diagnosed by a combination of low HGS and population-specific SMI cut-off (AC) best predicts mortality.
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