Evidence map›Paper›PMID 35068781›Full record

ArticleJournal of clinical and experimental hepatology

Kupffer Cell Hyaline Globules in Children With Autoimmune Hepatitis.

Mohammed A Khedr, Nermin M Adawy, Tahany A Salim, Menan E Salem, Ramy M Ghazy, Ahmed S Elharoun, Mervat M Sultan, Nermine A Ehsan

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Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammed A KhedrDepartment of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Egypt.
Nermin M AdawyDepartment of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Egypt.
Tahany A SalimDepartment of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Egypt.
Menan E SalemDepartment of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Egypt.
Ramy M GhazyTropical Health Department, High Institute of Public Health, Alexandria University, Egypt.
Ahmed S ElharounMicrobiology and Immunology Department, Faculty of Medicine, Menoufia University, Egypt.
Mervat M SultanDepartment of Pathology, National Liver Institute, Menoufia University, Egypt.
Nermine A EhsanDepartment of Pathology, National Liver Institute, Menoufia University, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyaline globules (HGs) in the cytoplasm of Kupffer cells (KCs) have been appraised for being a typical feature of autoimmune hepatitis (AIH). This study aimed to determine how useful Kupffer cell hyaline globules (KCHGs) are in diagnosing AIH vs. other causes of pediatric chronic liver diseases (PCLDs). MATERIALS AND

methodsThis retrospective study recruited 124 children; 58 with AIH, 50 with chronic hepatitis C virus (HCV) infection, and 16 with Wilson's disease (WD). Two pathologists retrieved paraffin blocks of liver biopsies and prepared new cut sections for Periodic acid-Schiff-Diastase (PAS-D) stain. They independently examined liver biopsies before starting treatment. Two pediatricians reviewed medical records for demographic, clinical, laboratory, and serological findings.

resultsFemales represented 48.6% of the studied children with a median age of 5.8 (4.9) years. Pathologists identified KCHGs in 67.24%, 12.5%, and 6.0% of AIH, WD, and HCV affected children respectively,

conclusionsKCHGs are key indicators that can differentiate between AIH and other PCLDs, and between seropositive and seronegative AIH.

Indexed as

AIH, Autoimmune hepatitisALP, Alkaline phosphataseALT, Alanine aminotransferaseAMA, Antimitochondrial antibodyANA, Antinuclear antibodyantiLC1, Antiliver cytosol type 1 antibodyAST, Aspartate aminotransferaseautoimmune hepatitisGGT, Gamma-glutamyl transpeptidaseHCV, Hepatitis C virusH&E, Hematoxylin and eosinhepatitis C virus infectionhyaline globulesIAIHG, International Autoimmune Hepatitis GroupKCHGs, Kupffer cell hyaline globulesKCs, Kupffer cellsKupffer cellsliver histopathologyLKMA, Liver-kidney microsome 1 antibodyPAS-D, Periodic acid–Schiff–DiastasePAS, Periodic Acid SchiffPCLD, Pediatric chronic liver diseaseSMA, Smooth muscle antibodyWBCs, White blood cell countWD, Wilson’s diseaseWilson’s disease

Identifiers

PMID35068781
PMCPMC8766698

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