Evidence map›Paper›PMID 35068780›Full record

ArticleJournal of clinical and experimental hepatology

Barriers for Liver Transplant in Patients with Alcohol-Related Hepatitis.

Gina Choi, Jihane N Benhammou, Jung J Yum, Elena G Saab, Ankur P Patel, Andrew J Baird, Stephanie Aguirre, Douglas G Farmer, Sammy Saab

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Gina ChoiDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jihane N BenhammouDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jung J YumDepartment of Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
Elena G SaabDepartment of Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
Ankur P PatelDepartment of Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
Andrew J BairdDepartment of Nursing, University of California, Los Angeles, Los Angeles, CA, USA.
Stephanie AguirreDepartment of Social Work, University of California, Los Angeles, Los Angeles, CA, USA.
Douglas G FarmerDepartment of Surgery, University of California, Los Angeles, Los Angeles, CA, USA.
Sammy SaabDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver transplantation (LT) for alcohol-related liver disease has historically been reserved for patients who have been six months abstinent. Given the increasing incidence of alcohol-related hepatitis (AH) and dismal survival in patients who fail medical therapy, transplant centers are extending their acceptance criteria for patients with less than 6 months of sobriety. We sought to determine the barriers for listing.

methodsWe conducted a retrospective chart review of all inpatient LT referrals for a diagnosis of AH between September 2019 and December 2020. LT evaluations were performed by a multidisciplinary team. Descriptive statistics were reported using mean and standard deviation (SD) or percentage where appropriate.

resultsDuring our study period, 82 patients were evaluated for LT. Of these 82 patients, 62 were declined for liver transplantation. The mean (SD) age of the 62-patient cohort was 44 years (10.7), and most patients were men. The mean (SD) number of reasons for denial was 2 (0.97). Four patients had medical contraindications for transplant. Twenty-seven (44%) and 35 (56%) patients lacked insight and were at risk of alcohol relapse, respectively. Forty-three (69%) and fourteen (22.5%) patients had insufficient social support and an inability to maintain a therapeutic relationship with the transplant team, respectively.

conclusionPatients are more likely denied for psychosocial factors than medical comorbidities. The majority were due to lack of insight, insufficient social support, and inability to maintain a therapeutic relationship with the transplant team. Resources should be allocated to address these issues.

Indexed as

AH, alcohol-related hepatitisalcohol hepatitisALD, alcohol-related liver diseaseINR, international normalized ratioIQR, interquartile rangeliver transplantpatient outcomeSD, standard deviation

Identifiers

PMID35068780
PMCPMC8766699
OpenAlexW3200043726

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.