ArticleIndian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
Retained Splenic Function in an Indian Population with Homozygous Sickle Cell Disease May Have Important Clinical Significance.
Article in Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Clinical and laboratory factors associated with splenic dysfunction among patients with sickle cell disease in a malaria endemic region.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
- Evaluation of two red cell inclusion staining methods for assessing spleen function among sickle cell disease patients in North-East Nigeria.PLOS global public health · 2023Article
- Spleen size in homozygous sickle cell disease: trends in a birth cohort using ultrasound.The British journal of radiology · 2022Article
- Odisha Revisited: A Personal Account.Frontiers in medicine · 2021Review
- Sickle Cell Disease: Thoughts for India From the Jamaican Cohort Study.Frontiers in medicine · 2021Review
- The Influence of Fetal Hemoglobin on Hematological Parameters and Clinical Severity in Patients with Homozygous Sickle Cell Disease.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
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3 authors at 1 institution in 1 country.
Funding
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Abstract
BACKGROUND AND
objectivesTo determine whether the persistence of splenomegaly characteristic of the Asian haplotype of homozygous sickle cell (SS) disease is associated with continued splenic function, a comparison of patients from Odisha, India, and Jamaica. MATERIALS AND
methodsIndian patients were examined in a cross-sectional study and compared with the Jamaican Cohort Study from birth. Splenomegaly was assessed in both populations with standard methods. Splenic function was assessed in both by counts of pitted red blood cells determined by differential interference contrast microscopy in the same laboratory.
resultsIn Jamaica, the spleen became palpable in 55% of patients during the 1 INTERPRETATION AND
conclusionsThe maximal risk of invasive pneumococcal infection in SS disease falls sharply after the age of 3 years, and persistence of splenic function in Odisha patients beyond this age may explain the apparent absence of pneumococcal septicemia in Indian patients and questions the role of pneumococcal prophylaxis.
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