ArticleJournal of Alzheimer's disease : JAD2022
Late-Life Physical Activities Moderate the Relationship of Amyloid-β Pathology with Neurodegeneration in Individuals Without Dementia.
Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical activity and amyloid beta in middle-aged and older adults: A systematic review and meta-analysis.Journal of sport and health science · 2024Pooled it
- Physical activity across the life course and neural biomarkers.Journal of Alzheimer's disease : JAD · 2026Article
- Lifetime walking and Alzheimer's pathology: A longitudinal study in older adults.The journal of prevention of Alzheimer's disease · 2025Article
- Psychometrics of the Lifetime Total Physical Activity Questionnaire in adults with a history of depression.Journal of Alzheimer's disease : JAD · 2025Article
- Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Association between physical activity and episodic memory and the moderating effects of the apolipoprotein E ε4 allele and age.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundPhysical activities (PA) have been suggested to reduce the risk of Alzheimer's disease (AD) dementia. However, information on the neuropathological links underlying the relationship is limited.
objectiveWe investigated the role of midlife and late-life PA with in vivo AD neuropathologies in old adults without dementia.
methodsThis study included participants from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease (KBASE). The participants underwent comprehensive clinical and neuropsychological assessment, [11C] Pittsburgh Compound B positron emission tomography (PET), [18F] fluorodeoxyglucose PET, and magnetic resonance imaging. Using the multi-modal brain imaging data, in vivo AD pathologies including global amyloid deposition, AD-signature region cerebral glucose metabolism (AD-CM), and AD-signature region cortical thickness (AD-CT) were quantified. Both midlife and late-life PA of participants were measured using the Lifetime Total Physical Activity Questionnaire.
resultsThis study was performed on 260 participants without dementia (195 with normal cognitive function and 65 with mild cognitive impairment). PA of neither midlife nor late-life showed direct correspondence with any neuroimaging biomarker. However, late-life PA moderated the relationship of brain amyloid-β (Aβ) deposition with AD-CM and AD-CT. Aβ positivity had a significant negative effect on both AD-CM and AD-CT in individuals with lower late-life PA, but those with higher late-life PA did not show such results. Midlife PA did not have such a moderation effect.
conclusionThe findings suggest that physically active lifestyle in late-life, rather than that in midlife, may delay AD-associated cognitive decline by decreasing Aβ-induced neurodegenerative changes in old adults.
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