ArticleEpidemiology and infection2022
Inferring SARS-CoV-2 RNA shedding into wastewater relative to the time of infection.
Article in Epidemiology and infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Real-time estimation of pathogen transmission dynamics from wastewater.Nature communications · 2026Article
- Evaluation and estimation of epidemic trajectories for SARS-CoV-2 from clinical and wastewater data in Gauteng Province, South Africa.PLOS global public health · 2026Article
- Wastewater Surveillance for SARS-CoV-2 in Northern Italy: An Evaluation of Three Different Gene Targets.Microorganisms · 2025Article
- Wastewater Based Measures of COVID-19 and Associations with Children's Absenteeism at Grade Schools.The Science of the total environment · 2025Article
- Wastewater-Based Epidemiology for SARS-CoV-2 in Northern Italy: A Spatiotemporal Model.International journal of environmental research and public health · 2024Article
- Making waves: Integrating wastewater surveillance with dynamic modeling to track and predict viral outbreaks.Water research · 2023Article
- Analysis of SARS-CoV-2 in wastewater for prevalence estimation and investigating clinical diagnostic test biases.Water research · 2023Article
- Using wastewater to overcome health disparities among rural residents.Geoforum; journal of physical, human, and regional geosciences · 2023Article
- Wastewater Surveillance Can Function as an Early Warning System for COVID-19 in Low-Incidence Settings.Tropical medicine and infectious disease · 2023Article
- Regional and temporal differences in the relation between SARS-CoV-2 biomarkers in wastewater and estimated infection prevalence - Insights from long-term surveillance.The Science of the total environment · 2023Article
- Evaluating various composite sampling modes for detecting pathogenic SARS-CoV-2 virus in raw sewage.Frontiers in microbiology · 2023Article
- Actionable wastewater surveillance: application to a university residence hall during the transition between Delta and Omicron resurgences of COVID-19.Frontiers in public health · 2023Article
- Timing and Trends for Municipal Wastewater, Lab-Confirmed Case, and Syndromic Case Surveillance of COVID-19 in Raleigh, North Carolina.American journal of public health · 2023Article
- Wastewater to clinical case (WC) ratio of COVID-19 identifies insufficient clinical testing, onset of new variants of concern and population immunity in urban communities.The Science of the total environment · 2022Article
- Article
- Population level SARS-CoV-2 fecal shedding rates determined via wastewater-based epidemiology.The Science of the total environment · 2022Article
- Predictive values of time-dense SARS-CoV-2 wastewater analysis in university campus buildings.The Science of the total environment · 2022Article
- High Sensitivity and Specificity of Dormitory-Level Wastewater Surveillance for COVID-19 during Fall Semester 2020 at Syracuse University, New York.International journal of environmental research and public health · 2022Article
- Metrics to relate COVID-19 wastewater data to clinical testing dynamics.Water research · 2022Article
- Inferring SARS-CoV-2 RNA shedding into wastewater relative to the time of infection - CORRIGENDUM.Epidemiology and infection · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the start of the coronavirus disease-2019 (COVID-19) pandemic, there has been interest in using wastewater monitoring as an approach for disease surveillance. A significant uncertainty that would improve the interpretation of wastewater monitoring data is the intensity and timing with which individuals shed RNA from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into wastewater. By combining wastewater and case surveillance data sets from a university campus during a period of heightened surveillance, we inferred that individual shedding of RNA into wastewater peaks on average 6 days (50% uncertainty interval (UI): 6-7; 95% UI: 4-8) following infection, and that wastewater measurements are highly overdispersed [negative binomial dispersion parameter, k = 0.39 (95% credible interval: 0.32-0.48)]. This limits the utility of wastewater surveillance as a leading indicator of secular trends in SARS-CoV-2 transmission during an epidemic, and implies that it could be most useful as an early warning of rising transmission in areas where transmission is low or clinical testing is delayed or of limited capacity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.