Evidence map›Paper›PMID 35068348›Full record

ArticleBioengineered2022

Circular RNA hsa_circ_0006091 as a novel biomarker for hepatocellular carcinoma.

Yongwei Zhang, Jun Li, Quanwei Cui, Panyi Hu, Shuangjiu Hu, Yeben Qian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yongwei ZhangDepartment of Gastrointestinal Surgery, Anqing First People's Hospital Affiliated to Anhui Medical University, Anhui, Anqing, China.
Jun LiDepartment of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Quanwei CuiDepartment of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Panyi HuDepartment of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Shuangjiu HuDepartment of Gastrointestinal Surgery, Anqing First People's Hospital Affiliated to Anhui Medical University, Anhui, Anqing, China.
Yeben QianDepartment of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Anhui Medical University · CNFirst Affiliated Hospital of Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are stable and extensively distributed non-coding RNA molecules that are differentially expressed in liver cancer tissues in the human body. In this study, we aimed to investigate circRNA as a novel candidate biomarker for hepatocellular carcinoma (HCC). For three groups of HCC and neighboring healthy tissues, the differentially expressed circRNAs were identified through high-throughput sequencing analysis. Reverse transcription PCR (RT-PCR) and quantitative polymerase chain reaction (qPCR) were employed for the evaluation of circRNAs that show an elevated expression level in HCC. The obtained results revealed the significantly differential expression of hsa_circ_0006091 in HCC. Then we obtained their target genes through biological analysis, followed by verifying the underlined target genes, and the regulator of G-protein signaling 12 (RGS12) showed an elevated expression level in HCC tissues. Finally, receiver operating characteristic (ROC) curve analysis was conducted on AFP, RGS12, and hsa_circ_0006091, and combined analysis was performed. Furthermore, hsa_circ_0006091 is a novel candidate biomarker for HCC and could improve the diagnostic strategies, prediction, and follow-up of HCC patients. The joint diagnosis of the hsa_circ_0006091&AFP and hsa_circ_0006091&RGS12 has diagnostic significance and can be used as a molecular marker for HCC diagnosis.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMicroRNAsalpha-FetoproteinsBiomarkersHumansRNARNA, CircularRNA, Messengeralpha-FetoproteinsBiomarkersMicroRNAsRNARNA, CircularRNA, Messengerbiological informationdiagnostic markersHepatocellular carcinomahsa_circ_0006091

Identifiers

PMID35068348
PMCPMC8973770
OpenAlexW4206910029

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.