Evidence map›Paper›PMID 35068339›Full record

ArticleBioengineered2022

Circular RNA Rbms1 inhibited the development of myocardial ischemia reperfusion injury by regulating miR-92a/BCL2L11 signaling pathway.

Ling Jin, Yuan Zhang, Yun Jiang, Mingjuan Tan, Caidong Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ling JinDepartment of Clinical Laboratory, Nanjing First Hospital, Affiliated to Nanjing Medical University, Nanjing, China.
Yuan ZhangDepartment of Clinical Laboratory, Nanjing First Hospital, Affiliated to Nanjing Medical University, Nanjing, China.
Yun JiangDepartment of Clinical Laboratory, Nanjing First Hospital, Affiliated to Nanjing Medical University, Nanjing, China.
Mingjuan TanDepartment of Clinical Laboratory, Nanjing First Hospital, Affiliated to Nanjing Medical University, Nanjing, China.
Caidong LiuDepartment of Clinical Laboratory, Nanjing First Hospital, Affiliated to Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myocardial infarction (AMI) is characterized by high morbidity and mortality rates. Circular RNAs collectively participate in the initiation and development of AMI. The purpose of this study was to investigate the role of circRbms1 in AMI. Ischemia-reperfusion (I/R) was performed to establish an AMI model. RT-qPCR and Western blotting were performed to detect mRNA and analyze protein expression, respectively. The interaction between miR-92a and circRbms1/BCL2L11 was confirmed by luciferase and RNA pull-down assays. circRbms1 is overexpressed in AMI. However, circRbms1 knockdown alleviated H9c2 cell apoptosis and reduced the release of reactive oxygen species. circRbms1 targeted miR-92a, the downregulation of which alleviated the effects of circRbms1 knockdown and increased oxidative stress and H9c2 cell apoptosis. Moreover, circRbms1 sponged miR-92a to upregulate BCL2L11, which modulated the expression of apoptosis-related genes. circRbms1 participated in myocardial I/R injury by regulating the miR-92a/BCL2L11 signaling pathway, which may provide a new strategy for the treatment of AMI.

Indexed as

AnimalsApoptosisBcl-2-Like Protein 11Cells, CulturedDisease ProgressionDNA-Binding ProteinsDown-RegulationGene Expression RegulationHumansMaleMiceMice, Inbred C57BLMicroRNAsMyocardial Reperfusion InjuryMyocytes, CardiacOxidative StressBcl-2-Like Protein 11DNA-Binding ProteinsMicroRNAsMIRN92 microRNA, humanMirn92 microRNA, mouseRBMS1 protein, humanRNA-Binding ProteinsRNA, CircularapoptosisBCL2L11circRbms1I/R injurymiR-92a

Identifiers

PMID35068339
PMCPMC8973616
OpenAlexW4206991842

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.