Evidence map›Paper›PMID 35068331›Full record

ArticleBioengineered2022

2-Methoxyestradiol combined with ascorbic acid facilitates the apoptosis of chronic myeloid leukemia cells via the microRNA-223/Fms-like tyrosine kinase 3/phosphatidylinositol-3 kinase/protein kinase B axis.

Suwei Zhang, Hanhui Yu, Jiazhen Li, Jingru Fan, Jingchao Chen

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Suwei ZhangDepartment of Clinical Laboratory, Shantou Central Hospital, Shantou,Guangdong, China.
Hanhui YuDepartment of Neurosurgery,Shantou Central Hospital, Shantou, Guangdong, China.
Jiazhen LiDepartment of Clinical Laboratory, Shantou Central Hospital, Shantou,Guangdong, China.
Jingru FanDepartment of Emergency,Shantou Central Hospital, Shantou, Guangdong, China.
Jingchao ChenDepartment of Clinical Laboratory, Shantou Central Hospital, Shantou,Guangdong, China.
Shantou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic myeloid leukemia (CML) is a malignant myeloproliferative tumor. 2-Methoxyestradiol (2-ME) is an endogenous estrogen metabolite that shows efficacy in human malignancies. Ascorbic acid (AA) possesses antioxidant activity. This study explored the mechanism of 2-ME combined with AA in the apoptosis of CML cells. Firstly, human CML cell lines were treated with 2-ME and AA. The cell viability, apoptosis, reactive oxygen species (ROS), and mitochondrial membrane potential (MMP) were detected. miR-223 expression in CML cells was detected. In addition, CML cells were transfected with miR-223 inhibitor. The binding relationship between miR-223 and FLT3 was verified. Subsequently, the FLT3 was overexpressed or silenced for the function rescue experiment to confirm the role of FLT3 in CML cell apoptosis. The expression levels of key factors of the PI3K/AKT pathway were detected. Finally, xenograft nude mouse models were established for

Indexed as

2-MethoxyestradiolAnimalsAscorbic Acidfms-Like Tyrosine Kinase 3HumansK562 CellsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMiceMicroRNAsProto-Oncogene Proteins c-aktRNA, NeoplasmSignal TransductionXenograft Model Antitumor Assays2-MethoxyestradiolAKT1 protein, humanAscorbic AcidFLT3 protein, humanfms-Like Tyrosine Kinase 3MicroRNAsMIR223, humanProto-Oncogene Proteins c-aktRNA, Neoplasm2-Methoxyestradiolapoptosisascorbic acidChronic myeloid leukemiaFLT3miR-223PI3K/AKT

Identifiers

PMID35068331
PMCPMC8973755
OpenAlexW4207072116

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.