SynthesisJournal of medical screening2022
Systematic review and meta-analysis of colon capsule endoscopy accuracy for colorectal cancer screening. An alternative during the Covid-19 pandemic?
Synthesis in Journal of medical screening, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
- Multicenter study of colon capsule endoscopy in post-polypectomy surveillance.Endoscopy international open · 2026Article
- Comment on Altobelli et al. Colon Capsule Endoscopy as a Promising Diagnostic Tool in Colorectal Cancer: A Systematic Review and Network Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Patient experience of colon capsule endoscopy in clinical practice: a structured, comparative patient survey.BMJ open gastroenterology · 2025Article
- Article
- Deep learning and capsule endoscopy: automatic panendoscopic detection of protruding lesions.BMJ open gastroenterology · 2025Article
- Multicentre Study of 10,369 Symptomatic Patients Comparing the Diagnostic Accuracy of Colon Capsule Endoscopy, Colonoscopy and CT Colonography.Alimentary pharmacology & therapeutics · 2025Article
- Review
- Colon capsule endoscopy today: Brief overview of leading UK and Danish initiatives.Endoscopy international open · 2025Review
- Evaluation of Colon Capsule Utilisation in Europe-CAPTURE EU Survey Findings.Journal of clinical medicine · 2024Article
- The Diagnostic Accuracy of Colon Capsule Endoscopy in Inflammatory Bowel Disease-A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2024Review
- Clinical and demographic features of patients undergoing video-capsule endoscopy management: A descriptive study.World journal of gastrointestinal endoscopy · 2024Article
- Conference Report: The FutuRE oF MinimalLy InvasivE GI and Capsule DiagnosTics (REFLECT) Nyborg, Denmark, October 2023.Diagnostics (Basel, Switzerland) · 2024Article
- Clinical utility of colon capsule endoscopy: a moving target?Therapeutic advances in gastroenterology · 2023Review
- Clinical presentation, management, screening and surveillance for colorectal cancer during the COVID-19 pandemic.World journal of clinical cases · 2022Review
- Colon Capsule Endoscopy in the Diagnosis of Colon Polyps: Who Needs a Colonoscopy?Diagnostics (Basel, Switzerland) · 2022Review
- The impact of COVID-19 pandemic in the diagnosis and management of colorectal cancer patients.Therapeutic advances in gastroenterology · 2022Review
- Systematic meta-review: diagnostic accuracy of colon capsule endoscopy for colonic neoplasia with umbrella meta-analysis.Therapeutic advances in gastrointestinal endoscopyArticle
- Optimizing bowel preparation regimens for colon capsule endoscopy: an umbrella review (overview of systematic reviews).Therapeutic advances in gastrointestinal endoscopyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the diagnostic accuracy of colon capsule endoscopy for colorectal cancer screening.
methodsStudies that compared the diagnostic performance of colonoscopy and second-generation colon capsule endoscopy (CCE-2) for screening of asymptomatic patients aged 50-75 years were included. The primary outcomes were sensitivity, specificity, and positive and negative likelihood ratios for polyps and adenomas measuring at least 6 mm or 10 mm.
resultsEight full-text studies that evaluated 1602 patients were included for systematic review. Of these, 840 (52.43%) patients participated in an opportunistic screening program. The pooled outcomes of CCE-2 for polyps at least 6 mm / 10 mm were (CI = confidence interval): sensitivity: 88% (95% CI: 0.84-0.91) / 88% (95% CI: 0.82-0.93), specificity: 94% (95% CI: 0.92-0.95) / 95.5% (95% CI: 0.94-0.97); positive likelihood ratio: 11.86 (95% CI: 5.53-25.46) / 23.07 (95% CI: 6.163-86.36); negative likelihood ratio: 0.14 (95% CI: 0.1-0.21) / 0.14 (95% CI: 0.09-0.21). The area under the summary receiver operating characteristic curve for polyps at least 6 and 10 mm was 96.3% and 96.7%, respectively. The only cancer missed by complete CCE-2 was shown at multiple frames in the unblinded review. In total, 125 (7.8%) patients presented mild adverse events mostly related to bowel preparation.
conclusionCCE-2 is demonstrated to be an effective and safe alternative method for colorectal cancer screening. Diagnostic performance of CCE-2 for polyps of at least 6 and 10 mm was similar. Completion rates still need to be improved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.