Evidence map›Paper›PMID 35068210›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2022

Testing lncRNAs signature as clinical stage-related prognostic markers in gastric cancer progression using TCGA database.

Narasimha M Beeraka, Hao Gu, Nannan Xue, Yang Liu, Huiming Yu, Junqi Liu, Kuo Chen, Vladimir N Nikolenko, Ruitai Fan

Open access · greenAbstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. lncHUB2: aggregated and inferred knowledge about human and mouse lncRNAs.Database : the journal of biological databases and curation · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Narasimha M BeerakaCancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Hao GuCancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Nannan XueCancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yang LiuDepartment of Radiotherapy, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450052, China.
Huiming YuDepartment of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 450052, China.
Junqi LiuCancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.ORCID 0000-0002-6015-1033
Kuo ChenCancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Vladimir N NikolenkoDepartment of Human Anatomy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow 119991, Russia.
Ruitai FanCancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.ORCID 0000-0003-3401-4315
First Affiliated Hospital of Zhengzhou University · CNSechenov University · RUPeking University · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LncRNA expression can be conducive to gastric cancer (GC) prognosis. The objective of this study is to ascertain five specific lncRNAs involved in tumor progression of GC and their role as prognostic markers to diagnose clinical stage-wise GC. High-throughput RNA sequencing data were obtained from The Cancer Genome Atlas (TCGA) database and performed genome-wide lncRNA expression analysis using edgeR package, Bioconductor.org, and R-statistical computing to analyze differentially expressed lncRNA analysis. Cutoff parameters were FDR < 0.05 and |Log2FC| > 2. Total 351 tumor samples with differentially expressed lncRNAs were divided into group-1 lncRNAs such as AC019117.2 and LINC00941, and group-2 lncRNAs such as LINC02410, AC012317.2, and AC141273.1 by 2:1. The Spearman correlation coefficients (

Indexed as

RNA, Long NoncodingStomach NeoplasmsGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansPrognosisRNA, MessengerRNA, Long NoncodingRNA, Messengerclinical stagegastric cancerGOKEGGlncRNA–mRNA interactionslncRNAsoverall survivalTCGA

Identifiers

PMID35068210
PMCPMC9039491
OpenAlexW4207006109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.