Evidence map›Paper›PMID 35068155›Full record

ArticleJournal of medicinal chemistry2022

Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A

Cristina Val, Carlos Rodríguez-García, Rubén Prieto-Díaz, Abel Crespo, Jhonny Azuaje, Carlos Carbajales, Maria Majellaro, Alejandro Díaz-Holguín, José M Brea, Maria Isabel Loza and 7 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Applying Deep-Learning-DrivenJournal of medicinal chemistry · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cristina ValCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Carlos Rodríguez-GarcíaCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Rubén Prieto-DíazCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.ORCID 0000-0003-2539-3106
Abel CrespoCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Jhonny AzuajeCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Carlos CarbajalesCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.ORCID 0000-0002-5177-3981
Maria MajellaroCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Alejandro Díaz-HolguínDepartment of Cell and Molecular Biology, Uppsala University, Uppsala 75124, Sweden.
José M BreaCentro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Maria Isabel LozaCentro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.ORCID 0000-0003-4730-0863
Claudia Gioé-GalloCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Marialessandra ContinoDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, via Orabona 4, Bari 70125, Italy.ORCID 0000-0002-0713-3151
Angela StefanachiDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, via Orabona 4, Bari 70125, Italy.ORCID 0000-0002-9430-7972
Xerardo García-MeraDepartamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.
Juan C EstévezCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.ORCID 0000-0001-9468-9045
Hugo Gutiérrez-de-TeránDepartment of Cell and Molecular Biology, Uppsala University, Uppsala 75124, Sweden.ORCID 0000-0003-0459-3491
Eddy SoteloCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.ORCID 0000-0001-5571-2812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A

Indexed as

Adenosine A1 Receptor AntagonistsBinding SitesCell LineDrug DesignDrug StabilityHumansKineticsMolecular Docking SimulationPyrimidinesReceptor, Adenosine A1Receptor, Adenosine A2AStructure-Activity RelationshipAdenosine A1 Receptor AntagonistsPyrimidinesReceptor, Adenosine A1Receptor, Adenosine A2A

Identifiers

PMID35068155
PMCPMC8842224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.