Evidence map›Paper›PMID 35068089›Full record

ArticleJournal of cachexia, sarcopenia and muscle2022

Muscle strength and prediabetes progression and regression in middle-aged and older adults: a prospective cohort study.

Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Duolao Wang, Tongzhi Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Shanhu QiuDepartment of General Practice, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.ORCID 0000-0003-2597-3856
Xue CaiDepartment of Nursing Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Yang YuanInstitute of Diabetes, School of Medicine, Southeast University, Nanjing, China.
Bo XieDepartment of General Practice, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Zilin SunInstitute of Diabetes, School of Medicine, Southeast University, Nanjing, China.
Duolao WangDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Tongzhi WuAdelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, SA, Australia.
Zhongda Hospital Southeast University · CNJinan University · CNLiverpool School of Tropical Medicine · GBThe University of Adelaide · AU

Funding

Guangdong Basic and Applied Basic Research Foundation 2020A1515111021National Key R&D Program of China 2016YFC1305700The Hospital Research Foundation
6 · The paper itself

Abstract

backgroundPrediabetes progression is associated with increased mortality while its regression decreases it. It is unclear whether muscle strength is related to prediabetes progression or regression. This study investigated the associations of muscle strength, assessed by grip strength and chair-rising time, with prediabetes progression and regression based on the China Health and Retirement Longitudinal Study (CHARLS) enrolling middle-aged and older adults.

methodsWe included 2623 participants with prediabetes from CHARLS, who were followed up 4 years later with blood samples collected for measuring fasting plasma glucose and haemoglobin A1c. Grip strength (normalized by body weight) and chair-rising time were assessed at baseline and categorized into tertiles (low, middle, and high groups). Prediabetes at baseline and follow-up was defined primarily using the American Diabetes Association (ADA) criteria and secondarily using the World Health Organization (WHO) and International Expert Committee (IEC) criteria. Multinomial logistic regression analysis was applied to obtain the odds ratios (ORs) and 95% confidence intervals (CIs).

resultsThe mean age of included participants was 59.0 ± 8.6 years, and 46.6% of them were males. During follow-up, 1646 participants remained as prediabetes, 379 progressed to diabetes, and 598 regressed to normoglycaemia based on ADA criteria. Participants who progressed to diabetes had lower normalized grip strength than those who remained as prediabetes (0.49 ± 0.15 vs. 0.53 ± 0.15, P < 0.001), but participants who regressed to normoglycaemia showed the opposite (0.55 ± 0.16 vs. 0.53 ± 0.15, P = 0.003). However, chair-rising time was comparable across different groups (P

conclusionsHigh muscle strength is associated with reduced odds of progression to diabetes but does not predict regression to normoglycaemia in prediabetes. Future studies are warranted to assess whether increases in muscle strength promote prediabetes regression.

Indexed as

Prediabetic StateAgedBlood GlucoseHand StrengthHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesBlood GlucoseCohortMuscle strengthPrediabetes progressionPrediabetes regression

Identifiers

PMID35068089
PMCPMC8978008
OpenAlexW4207027180

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.