Evidence map›Paper›PMID 35068071›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Bortezomib-Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy.

Mingyu Chen, Sarun Juengpanich, Shijie Li, Win Topatana, Ziyi Lu, Qiang Zheng, Jiasheng Cao, Jiahao Hu, Esther Chan, Lidan Hou and 7 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Mingyu ChenDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.ORCID 0000-0001-5113-754X
Sarun JuengpanichDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.ORCID 0000-0002-1449-5564
Shijie LiDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.ORCID 0000-0002-7583-4523
Win TopatanaDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.ORCID 0000-0001-8580-1920
Ziyi LuDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.ORCID 0000-0002-8209-3188
Qiang ZhengDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.
Jiasheng CaoDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.
Jiahao HuDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.
Esther ChanSchool of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.
Lidan HouDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.
Jiang ChenDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.
Fang ChenDepartment of Chemistry, Zhejiang University, Hangzhou, 310027, China.
Yu LiuCollege of Life Sciences, Zhejiang University, Hangzhou, 310058, China.
Sukanda JiansirisomboonSchool of Ceramic Engineering, Institute of Engineering, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.ORCID 0000-0001-5015-7370
Zhen GuDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.ORCID 0000-0003-2947-4456
Suparat TongpengSchool of Ceramic Engineering, Institute of Engineering, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand.ORCID 0000-0001-8721-3743
Xiujun CaiDepartment of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, 310016, China.ORCID 0000-0002-6457-0577
Sir Run Run Shaw Hospital · CNSuranaree University of Technology · THZhejiang University · CNNanyang Technological University · SG

Funding

Key Research and Development Project of Zhejiang Province 2018C03083National Natural Science Foundation of China 81800540National Natural Science Foundation of China 81827804SRRSH of Medicine Institutional Review Board KY20210712-43SRRSH of Medicine Institutional Review Board SRRSH202107064Zhejiang Clinical Research Center of Minimally Invasive Diagnosis and Treatment of Abdominal Diseases 2018E50003Zhejiang Provincial Natural Science Foundation of China LQ22H160003
6 · The paper itself

Abstract

Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As a proteasome inhibitor, bortezomib (BTZ) exhibits excellent antitumor ability in GBC. However, the long-term treatment efficacy is limited by its resistance, poor stability, and high toxicity. Herein, BTZ-encapsulated pH-responsive copolymeric nanoparticles with estrone (ES-NP

Indexed as

Antineoplastic AgentsGallbladder NeoplasmsNanoparticlesAnimalsBortezomibHumansProteasome InhibitorsTumor MicroenvironmentAntineoplastic AgentsBortezomibProteasome Inhibitorsdrug deliverygallbladder cancernanomedicineproteasome inhibitortargeted therapy

Identifiers

PMID35068071
PMCPMC8895115
OpenAlexW4206925226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.