Evidence map›Paper›PMID 35067985›Full record

ReviewJournal of neuroendocrinology2022

Development of the gonadotropin-releasing hormone system.

Anne H Duittoz, Paolo E Forni, Paolo Giacobini, Matan Golan, Patrice Mollard, Ariel L Negrón, Sally Radovick, Susan Wray

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of neuroendocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Genetics of Idiopathic Hypogonadotropic HypogonadismJournal of clinical research in pediatric endocrinology · 2026
    Review
  4. Review
  5. Knockout of PI4-Kinase A in GnRH Neurons Causes their Prepubertal Death.bioRxiv : the preprint server for biology · 2026
    Article
  6. De novo rare EMX2 variants lead to idiopathic hypogonadotropic hypogonadism.Genetics in medicine : official journal of the American College of Medical Genetics · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. GnRH and Cognition.Endocrinology · 2025
    Review
  15. Shifting GnRH Neuron Ensembles Underlie Successive Preovulatory Luteinizing Hormone Surges.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Anne H DuittozCNRS, IFCE, INRAE, Université de Tours, PRC, Nouzilly, France.ORCID 0000-0002-3981-4664
Paolo E ForniDepartment of Biological Sciences, University at Albany, Albany, NY, USA.ORCID 0000-0001-6547-3464
Paolo GiacobiniLaboratory of Development and Plasticity of the Postnatal Brain, Lille Neuroscience & Cognition, UMR-S1172, Inserm, CHU Lille, University of Lille, Lille, France.ORCID 0000-0002-3075-1441
Matan GolanInstitute of Animal Sciences, Agricultural Research Organization - Volcani Center, Rishon Letziyon, Israel.ORCID 0000-0003-4861-5912
Patrice MollardInstitute of Functional Genomics, CNRS, Inserm, Montpellier University, Montpellier, France.ORCID 0000-0002-2324-7589
Ariel L NegrónClinical and Translational Research, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID 0000-0001-8837-4354
Sally RadovickClinical and Translational Research, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.ORCID 0000-0002-8391-8583
Susan WrayCellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7670-3915
Rutgers, The State University of New Jersey · USAgricultural Research Organization · ILCentre National de la Recherche Scientifique · FRInserm · FRNational Institutes of Health · USUniversité de Tours · FRUniversity at Albany, State University of New York · US

Funding

Development And Regulation Of The Luteinizing Hormone Releasing Hormone SystemZIANS002824 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WRAY, SUSAN · 2009 to 2025
$41.2M
Sex Steroids, Kisspeptin and Regulation of GnRHR01HD068777 · NICHD · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI HOFFMAN, GLORIA E, LEVINE, JON E · 2012 to 2016
$2.4M
Understanding the role of the transcription factor Gli3 in Kallmann syndrome and normosmic forms of idiopathic hypogonadotropic hypogonadism.R01HD097331 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Paolo E Forni · 2019 to 2026
$2.2M
Molecular Mechanisms Controlling Differentiation and Circuit Formation of Vomeronasal Sensory NeuronsR01DC017149 · NIDCD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI FORNI, PAOLO E · 2019 to 2023
$1.8M
Role of inductive signals released by nasal mesenchyme and brain in controlling terminal nerve development and GnRH-1 neuronal migrationR15HD096411 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI FORNI, PAOLO E · 2018 to 2018
$450k
Intramural NIH HHS ZIA NS002824NICHD NIH HHS R01 HD068777NICHD NIH HHS R01 HD097331NICHD NIH HHS R15 HD096411NIDCD NIH HHS R01 DC017149
6 · The paper itself

Abstract

This review summarizes the current understanding of the development of the neuroendocrine gonadotropin-releasing hormone (GnRH) system, including discussion on open questions regarding (1) transcriptional regulation of the Gnrh1 gene; (2) prenatal development of the GnRH1 system in rodents and humans; and (3) paracrine and synaptic communication during migration of the GnRH cells.

Indexed as

Gonadotropin-Releasing HormoneNeuronsFemaleGene Expression RegulationHumansNeurosecretory SystemsPregnancyGonadotropin-Releasing HormonedevelopmentGnRHguidance cuesmigratory pathwayolfactory ensheathing cellsolfactory placodesynaptic and paracrine signalsterminal nervetranscription factors

Identifiers

PMID35067985
PMCPMC9286803
OpenAlexW4200526272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.