Evidence map›Paper›PMID 35067981›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2022

Cortical Bone Loss Following Gastric Bypass Surgery Is Not Primarily Endocortical.

Saghi Sadoughi, Courtney Pasco, Gabby B Joseph, Po-Hung Wu, Anne L Schafer, Galateia J Kazakia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saghi SadoughiMusculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.ORCID 0000-0003-0308-9189
Courtney PascoMusculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Gabby B JosephMusculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Po-Hung WuMusculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Anne L SchaferDepartment of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0002-4750-9125
Galateia J KazakiaMusculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Skeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 2019 to 2026
$7.1M
Progression and etiology of cortical porosity in diabetic bone diseaseR01AR069670 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J · 2017 to 2023
$2.9M
Effects of Sleeve Gastrectomy on Calcium Metabolism and the SkeletonR01DK107629 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SCHAFER, ANNE LOUISE · 2016 to 2020
$2.4M
In vivo imaging of cortical porosity in the peripheral skeletonK01AR056734 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J · 2009 to 2013
$594k
Prebiotic Intervention to Improve Calcium Absorption After Gastric Bypass SurgeryR21DK112126 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SCHAFER, ANNE LOUISE · 2017 to 2018
$448k
Visualizing Cortical Pore Space ConstituentsR03AR064004 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAZAKIA, GALATEIA J · 2013 to 2015
$186k
Effects of Gastric Bypass Surgery on Calcium Metabolism and the SkeletonIK2CX000549 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI SCHAFER, ANNE LOUISE · 2011 to 2015
–
CSRD VA IK2 CX000549NCATS NIH HHS UL1 TR000004NIAMS NIH HHS K01 AR056734NIAMS NIH HHS P30 AR075055NIAMS NIH HHS R01 AR069670NIAMS NIH HHS R03 AR064004NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK107629NIDDK NIH HHS R21 DK112126U.S. Department of Veterans Affairs 5 IK2 CX000549
6 · The paper itself

Abstract

Roux-en Y gastric bypass (RYGB) surgery is an effective treatment for obesity; however, it may negatively impact skeletal health by increasing fracture risk. This increase may be the result not only of decreased bone mineral density but also of changes in bone microstructure, for example, increased cortical porosity. Increased tibial and radial cortical porosity of patients undergoing RYGB surgery has been observed as early as 6 months postoperatively; however, local microstructural changes and associated biological mechanisms driving this increase remain unclear. To provide insight, we studied the spatial distribution of cortical porosity in 42 women and men (aged 46 ± 12 years) after RYGB surgery. Distal tibias and radii were evaluated with high-resolution peripheral quantitative computed tomography (HR-pQCT) preoperatively and at 12 months postoperatively. Laminar analysis was used to determine cortical pore number and size within the endosteal, midcortical, and periosteal layers of the cortex. Paired t tests were used to compare baseline versus follow-up porosity parameters in each layer. Mixed models were used to compare longitudinal changes in laminar analysis outcomes between layers. We found that the midcortical (0.927 ± 0.607 mm

Indexed as

Gastric BypassBone and BonesBone DensityCortical BoneFemaleHumansMaleRadiusTibiaBONE MICROSTRUCTURECORTICAL POROSITYGASTRIC BYPASS SURGERYHR-pQCTLAMINAR ANALYSIS

Identifiers

PMID35067981
PMCPMC9071182

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.