Trial reportActa paediatrica (Oslo, Norway : 1992)2022
Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm.
Trial report in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The effects of short- and long-duration Kangaroo Mother Care and conventional care on improving weight gain in low birth weight infants: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Immediate Skin-to-Skin Contact in Very Preterm Neonates and Early Childhood Neurodevelopment: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Skin-to-Skin Contact at Birth for Very Preterm Infants and Mother-Infant Interaction Quality at 4 Months: A Secondary Analysis of the IPISTOSS Randomized Clinical Trial.JAMA network open · 2023Trial
- Kangaroo mother care had a protective effect on the volume of brain structures in young adults born preterm.Acta paediatrica (Oslo, Norway : 1992) · 2022Trial
- From oxidative stress to epigenetic regulation: Molecular mechanisms of preterm brain injury and neuroprotective strategies (Review).Molecular medicine reports · 2026Review
- Kangaroo Care as an intervention in randomised controlled trials in neonatal intensive care.Pediatric research · 2026Review
- Immediate kangaroo mother care: a narrative review of the benefits and barriers.World journal of pediatrics : WJP · 2026Review
- The Swedish national guideline on immediate and uninterrupted skin-to-skin contact and mother-newborn couplet care.Frontiers in pediatrics · 2026Article
- Kangaroo Method Care: Benefits, Proponents and Barriers: A Narrative Review.Iranian journal of public health · 2025Review
- Skin-to-Skin Holding in Relation to White Matter Microstructure in Infants Born Preterm.Neurology · 2025Observational
- Preterm Infants Without Neurological Damage and Nursery Care: Risks, Benefits and Prospects for Intervention.Children (Basel, Switzerland) · 2025Article
- Immediate Skin-to-Skin Contact at Very Preterm Birth and Neurodevelopment the First Two Years: Secondary Outcomes from a Randomised Clinical Trial.Children (Basel, Switzerland) · 2025Article
- The shifting landscape of the preterm brain.Neuron · 2025Review
- Obstetric and neonatal conditions and associations with early skin-to-skin contact - a cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Emergence of a synergistic scaffold in the brains of human infants.Communications biology · 2025Article
- Skin-to-skin holding in relation to white matter connectivity in infants born preterm.medRxiv : the preprint server for health sciences · 2025Article
- Brain volumes are related with motor skills at late childhood in children born extremely preterm.PloS one · 2025Article
- An interdisciplinary fetal neonatal neurology collaborative promotes integrative life-course brain health.Frontiers in neurology · 2025Review
- Inpatient Skin-to-skin Care Predicts 12-Month Neurodevelopmental Outcomes in Very Preterm Infants.The Journal of pediatrics · 2024Article
- Monitoring lung and cerebral oxygenation using near-infrared spectroscopy in preterm infants during kangaroo mother care.European journal of pediatrics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
aimThe protective effects of Kangaroo mother care (KMC) on the neurodevelopment of preterm infants are well established, but we do not know whether the benefits persist beyond infancy. Our aim was to determine whether providing KMC in infancy affected brain volumes in young adulthood.
methodStandardised cognitive, memory and motor skills tests were used to determine the brain volumes of 20-year-old adults who had formed part of a randomised controlled trial of KMC versus incubator care. Multivariate analysis of brain volumes was conducted according to KMC exposure.
resultsThe study comprised 178 adults born preterm: 97 had received KMC and 81 were incubator care controls. Bivariate analysis showed larger volumes of total grey matter, basal nuclei and cerebellum in those who had received KMC, and the white matter was better organised. This means that the volumes of the main brain structures associated with intelligence, attention, memory and coordination were larger in the KMC group. Multivariate lineal regression analysis demonstrated the direct relationship between brain volumes and duration of KMC, after controlling for potential confounders.
conclusionOur findings suggest that the neuroprotective effects of KMC for preterm infants persisted beyond childhood and improved their lifetime functionality and quality of life.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.