ArticleLasers in surgery and medicine2022
Clinical endpoints of needle-free jet injector treatment: An in depth understanding of immediate skin responses.
Article in Lasers in surgery and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology-a systematic review.Drug delivery and translational research · 2023Pooled it
- Advances in the treatment of acne scars.Frontiers in medicine · 2025Review
- Traumatic vitreous hemorrhage and choroidal rupture after needleless Dermojet injection to the eyebrow.American journal of ophthalmology case reports · 2024Article
- Needle-Free Jet Injection of Poly-(Lactic Acid) for Atrophic Acne Scars: Literature Review and Report of Clinical Cases.Journal of clinical medicine · 2024Review
- Needle-Free Jet Injector-Assisted Triamcinolone Treatment of Keloids and Hypertrophic Scars is Effective and Well Tolerated in Children.Clinical drug investigation · 2024Article
- Needle-free intradermal vaccination, an opportunity to improve commercial pig welfare.Animal welfare (South Mimms, England) · 2024Article
- Needle-free electronically controlled jet injection with corticosteroids in recalcitrant keloid scars: a retrospective study and patient survey.Lasers in medical science · 2023Article
- Dynamic interaction of injected liquid jet with skin layer interfaces revealed by microsecond imaging of optically cleared ex vivo skin tissue model.Journal of biological engineering · 2023Article
- Clinical endpoints of needle-free jet injector treatment: An in depth understanding of immediate skin responses.Lasers in surgery and medicine · 2022Article
- Needle-free jet injection-induced small-droplet aerosol formation during intralesional bleomycin therapy.Lasers in surgery and medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNeedle-free jet injectors have been used in dermatological practice for many years. However, predefined clinical endpoints that guide physicians to choose optimal device settings have not been clearly defined. Here, we evaluate immediate skin responses as clinical endpoints for needle-free jet injector treatments.
methodsWe injected methylene blue in ex vivo human skin using an electronically-controllable pneumatic injector (EPI; 3-6 bar, 50-130 µl; n = 63), and a spring-loaded jet injector (SLI) with fixed settings (100 µl; n = 9). We measured the immediate skin papule (3D-camera), residual surface fluid (pipette), dermal dye distribution by estimating depth and width, and subcutaneous dye deposition.
resultsEPI with 4 bar and 100 µl resulted in the largest skin papule of 48.7 mm
conclusionsThe immediate skin papule and residual surface fluid correspond with dermal drug deposition and are relevant clinical endpoints for needle-free jet injector treatments in dermatological practice.
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