Evidence map›Paper›PMID 35067819›Full record

Trial reportQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022

Quality of life after stroke: a longitudinal analysis of a cluster randomized trial.

Zhomart Orman, Amanda G Thrift, Muideen T Olaiya, David Ung, Dominique A Cadilhac, Thanh Phan, Mark R Nelson, Velandai K Srikanth, Jason Vuong, Christopher F Bladin and 5 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  7. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Zhomart OrmanStroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia. zhomart.orman@monash.edu.ORCID http://orcid.org/0000-0002-0223-4236
Amanda G ThriftStroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia.
Muideen T OlaiyaStroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia.
David UngStroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia.
Dominique A CadilhacStroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia.ORCID http://orcid.org/0000-0001-8162-682X
Thanh PhanStroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia.
Mark R NelsonMenzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.
Velandai K SrikanthPeninsula Clinical School, Central Clinical School, Monash University, Frankston, VIC, Australia.
Jason VuongStroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia.
Christopher F BladinEastern Health Clinical School, Box Hill, VIC, Australia.
Richard P GerratyDepartment of Medicine, Epworth Healthcare, Richmond, VIC, Australia.
Sharyn M FitzgeraldDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Judith FrayneDepartment of Neurology, Alfred Hospital, Melbourne, VIC, Australia.
Joosup KimStroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia.
STANDFIRM (Shared Team Approach between Nurses and Doctors For Improved Risk factor Management) Investigators
Monash Health · AUMonash Medical Centre · AUThe University of Melbourne · AUUniversity of Tasmania · AUAmbulance Victoria · AUEpworth Hospital · AUMonash University · AUThe Alfred Hospital · AU

Funding

National Health and Medical Research Council 586605
6 · The paper itself

Abstract

purposeHealth-related quality of life (QoL) is poor after stroke, but may be improved with comprehensive care plans. We aimed to determine the effects of an individualized management program on QoL in people with stroke or transient ischemic attack (TIA), describe changes in QoL over time, and identify variables associated with QoL.

methodsThis was a multicenter, cluster randomized controlled trial with blinded assessment of outcomes and intention-to-treat analysis. Patients with stroke or TIA aged ≥ 18 years were randomized by general practice to receive usual care or an intervention comprising a tailored chronic disease management plan and education. QoL was assessed at baseline and 3, 12, and 24 months after baseline using the Assessment of Quality of Life instrument. Patient responses were converted to utility scores ranging from - 0.04 (worse than death) to 1.00 (good health). Mixed-effects models were used for analyses.

resultsAmong 563 participants recruited (mean age 68.4 years, 64.5% male), median utility scores ranged from 0.700 to 0.772 at different time points, with no difference observed between intervention and usual care groups. QoL improved significantly from baseline to 3 months (ß = 0.019; P = 0.015) and 12 months (ß = 0.033; P < 0.001), but not from baseline to 24 months (ß = 0.013; P = 0.140) in both groups combined. Older age, females, lower educational attainment, greater handicap, anxiety and depression were longitudinally associated with poor QoL.

conclusionAn individualized management program did not improve QoL over 24 months. Those who are older, female, with lower educational attainment, greater anxiety, depression and handicap may require greater support. CLINICAL

trial registrationhttps://www.anzctr.org.au . Unique identifier: ACTRN12608000166370.

Indexed as

Ischemic Attack, TransientStrokeAgedAnxietyFemaleHumansMaleQuality of LifeChronic disease managementQuality of lifeRandomized controlled trialStroke

Identifiers

PMID35067819
OpenAlexW4206996214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.