Evidence map›Paper›PMID 35067755›Full record

ArticleEuropean journal of nutrition2022

Associations between intake of dietary flavonoids and the 10-year incidence of tinnitus in older adults.

Diana Tang, Yvonne Tran, Joshua R Lewis, Nicola P Bondonno, Catherine P Bondonno, Jonathan M Hodgson, Deepti Domingo, David McAlpine, George Burlutsky, Paul Mitchell and 2 more

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In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Tinnitus.Nature reviews. Disease primers · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
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  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Diana TangDepartment of Linguistics, Macquarie University Hearing, Australian Hearing Hub, Macquarie University, 16 University Avenue, Balaclava Road, Macquarie Park, NSW, 2109, Australia. d.tang@mq.edu.au.ORCID http://orcid.org/0000-0003-2007-9054
Yvonne TranDepartment of Linguistics, Macquarie University Hearing, Australian Hearing Hub, Macquarie University, 16 University Avenue, Balaclava Road, Macquarie Park, NSW, 2109, Australia.
Joshua R LewisSchool of Public Health, Centre for Kidney Research, Westmead, University of Sydney, Camperdown, NSW, 2006, Australia.
Nicola P BondonnoInstitute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, PerthJoondalup, WA, 6027, Australia.
Catherine P BondonnoInstitute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, PerthJoondalup, WA, 6027, Australia.
Jonathan M HodgsonInstitute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, PerthJoondalup, WA, 6027, Australia.
Deepti DomingoCollege of Nursing and Health Sciences, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.
David McAlpineDepartment of Linguistics, Macquarie University Hearing, Australian Hearing Hub, Macquarie University, 16 University Avenue, Balaclava Road, Macquarie Park, NSW, 2109, Australia.
George BurlutskyDepartment of Ophthalmology and Westmead Institute for Medical Research, Centre for Vision Research, University of Sydney, Camperdown, NSW, 2006, Australia.
Paul MitchellDepartment of Ophthalmology and Westmead Institute for Medical Research, Centre for Vision Research, University of Sydney, Camperdown, NSW, 2006, Australia.
Giriraj S ShekhawatCollege of Nursing and Health Sciences, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia.
Bamini GopinathDepartment of Linguistics, Macquarie University Hearing, Australian Hearing Hub, Macquarie University, 16 University Avenue, Balaclava Road, Macquarie Park, NSW, 2109, Australia.
Edith Cowan University · AUAustralian Hearing · AUThe University of Sydney · AUFlinders University · AU

Funding

Australian National Health and Medical Research Council 211069Australian National Health and Medical Research Council 262120Australian National Health and Medical Research Council 974159Australian National Health and Medical Research Council 991407
6 · The paper itself

Abstract

purposeDietary flavonoids are bioactive compounds that have been widely investigated for their associations with vascular health outcomes. As the development of tinnitus has been linked to vascular pathways, dietary flavonoids may have role in the prevention of tinnitus symptoms. This study reports the associations between the intakes of major classes of dietary flavonoids and 10-year incidence of tinnitus.

methodsOf the 1753 participants (aged ≥ 50 years) from the Blue Mountains Hearing Study with complete baseline data on tinnitus symptoms and dietary intakes, 536 (31%) cases of tinnitus were identified and excluded from further analysis. Dietary data was collected using a semi-quantitative food frequency questionnaire and intakes of the five major classes of flavonoids were determined using U.S. Department of Agriculture flavonoid databases. Presence of prolonged tinnitus was assessed by a positive response to a single question administered by an audiologist.

resultsOf the remaining 1217 participants without tinnitus at baseline, 222 (18%) incident cases of tinnitus were identified over 10 years. After age-sex adjustment, participants in the third versus first quartile of proanthocyanidin intake were significantly less likely to develop incident tinnitus by 36% (HR = 0.64; 95% CI 0.43-0.96, P

conclusionOur findings do not support the hypothesis that dietary flavonoids are protective against the development of tinnitus over 10 years. The weak significant association observed between proanthocyanidin and incident tinnitus may be a chance finding as there was no significant trend following multivariate adjustments and, therefore, requires further studies to investigate these associations.

Indexed as

ProanthocyanidinsTinnitusAgedDietFlavonoidsHumansIncidencePolyphenolsRisk FactorsFlavonoidsPolyphenolsProanthocyanidinsBlue Mountains Hearing StudyFlavonoidsOlder adultsTinnitus

Identifiers

PMID35067755
OpenAlexW4206955762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.