Evidence map›Paper›PMID 35067753›Full record

Trial reportEuropean journal of nutrition2022

The effects of fish oil plus vitamin D

Xiao-Fei Guo, Chong Wang, Ting Yang, Wen-Jun Ma, Jie Zhai, Ting Zhao, Tong-Cheng Xu, Jun Li, He Liu, Andrew J Sinclair and 1 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Xiao-Fei GuoInstitute of Nutrition & Health, Qingdao University, 308 Ningxia Road, Qingdao, China.
Chong WangInstitute of Nutrition & Health, Qingdao University, 308 Ningxia Road, Qingdao, China.
Ting YangInstitute of Nutrition & Health, Qingdao University, 308 Ningxia Road, Qingdao, China.
Wen-Jun MaInstitute of Nutrition & Health, Qingdao University, 308 Ningxia Road, Qingdao, China.
Jie ZhaiSongshan Hospital of Qingdao University, Qingdao, China.
Ting ZhaoAffiliated Hospital of Qingdao University, Qingdao, China.
Tong-Cheng XuShandong Academy of Agriculture Sciences, Jinan, China.
Jun LiCollege of Food Science and Technology, Bohai University, Jinzhou, China.
He LiuCollege of Food Science and Technology, Bohai University, Jinzhou, China.
Andrew J SinclairDepartment of Nutrition, Dietetics and Food, Monash University, Notting Hill, Australia.
Duo LiInstitute of Nutrition & Health, Qingdao University, 308 Ningxia Road, Qingdao, China. duoli@qdu.edu.cn.
Qingdao University · CNBohai University · CNMonash University · AUShandong Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe present study aimed to investigate fish oil plus vitamin D

methodsIn a 3-month randomized controlled trial, 111 subjects with NAFLD, aged 56.0 ± 15.9 y, were randomized into FO + D group (n = 37), fish oil group (FO, n = 37) or corn oil group (CO, n = 37). The subjects consumed the following capsules (3 g/day), which provided 2.34 g/day of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) + 1680 IU vitamin D

resultsUsing multivariable-adjusted general linear model, there were significant net reductions in serum alanine aminotransferase (ALT), and triacylglycerol (TAG) and TNF-α levels in the FO + D and FO groups, compared with the control group (P < 0.05). The supplemental FO + D also showed significant reductions in insulin (- 1.58 ± 2.00 mU/L vs. - 0.63 ± 1.55 mU/L, P = 0.050) and IL-1β (- 6.92 ± 7.29 ng/L vs. 1.06 ± 5.83 ng/L, P < 0.001) in comparison with control group. Although there were no significant differences between FO + D and FO groups regarding biochemical parameters, supplemental FO + D showed decreases in ALT (from 26.2 ± 13.5 U/L to 21.4 ± 9.6 U/L, P = 0.007), aspartate aminotransferase (AST, from 22.5 ± 7.0 U/L to 20.2 ± 4.0 U/L, P = 0.029), HOMA-IR (from 3.69 ± 1.22 to 3.38 ± 1.10, P = 0.047), and TNF-α (from 0.43 ± 0.38 ng/L to 0.25 ± 0.42 ng/L, P < 0.001) levels following the intervention.

conclusionThe present study demonstrated that groups supplemented with FO + D and FO had similar beneficial effects on biomarkers of hepatocellular damage and plasma TAG levels in subjects with NAFLD, while in the FO + D group, there were some suggestive additional benefits compared with FO group on insulin levels and inflammation.

trial registrationChiCTR1900024866.

Indexed as

CholecalciferolFish OilsNon-alcoholic Fatty Liver DiseaseBiomarkersDietary SupplementsDocosahexaenoic AcidsEicosapentaenoic AcidHumansInsulinMiddle AgedTriglyceridesTumor Necrosis Factor-alphaBiomarkersCholecalciferolDocosahexaenoic AcidsEicosapentaenoic AcidFish OilsInsulinTriglyceridesTumor Necrosis Factor-alphaFish oilNon-alcoholic fatty liver diseaseRandomized controlled trialVitamin D3

Identifiers

PMID35067753
OpenAlexW4206952982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.